相关实验视频

Updated: May 6, 2026

Transoral Endoscopic Thyroidectomy Vestibular Approach for Thyroid Lobectomy

Transoral Endoscopic Thyroidectomy Vestibular Approach for Thyroid Lobectomy

Published on: May 12, 2023

甲状腺切除术不进行淋巴结解剖应考虑T1阶段的甲状腺髓性癌症:基于人口的队列研究

Zixia Tao¹, Xianzhao Deng¹, Zheng Ding¹

¹Department of General Surgery, Thyroid and Parathyroid Center, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Frontiers in endocrinology

|September 13, 2024

概括

淋巴结解剖 (LND) 对早期T1髓性甲状腺癌 (MTC) 患者没有生存益处. 避免常规的LND可能会改善生活质量,而不会影响预后,因此需要进一步研究.

科学领域:

在瘤学瘤学.
手术瘤学手术瘤学
内分泌学在内分泌学.

背景情况:

在T1髓性甲状腺癌 (MTC) 早期阶段进行淋巴结解剖 (LND) 的必要性受到争议.
目前的指导方针经常建议LND,但其在这个特定的患者群体中的治疗价值仍然存在争议.

研究的目的:

为了研究淋巴结解剖 (LND) 对早期T1髓性甲状腺癌 (MTC) 患者的生存结果的影响.
在T1 MTC中识别与淋巴结转移相关的因素.
为了比较接受LND和没有接受LND的患者之间的生存率和预后.

主要方法:

利用监测,流行病学和最终结果 (SEER) 数据库来识别T1MTC患者.
采用波桑回归来分析促进淋巴结转移的因素.
应用倾向分数匹配 (PSM) 来控制LND和非LND组之间的基线差异.
使用卡普兰-梅尔方法和考克斯回归来评估生存结果.

主要成果:

在1231名T1MTC患者中,72.0%接受了LND,22.0%发生了淋巴结转移.
年龄较小,男性性别,瘤大小 (>10mm) 与转移风险较高有关.
与非LND相比,LND没有显著的整体存活率 (OS) 或疾病特异性存活率 (DSS) 的好处,即使在PSM之后.
亚组分析证实LND没有预测优势.

结论:

早期T1 MTC患者往往患有淋巴结转移的风险较低.
避免常规LND可能提供与标准程序相似的预后,同时可能提高生活质量.
需要进一步的大规模前性多中心研究来验证这些发现.

关键词:

塞尔·塞尔 (Seer) 是一个看得见的人.淋巴结解剖淋巴结解剖淋巴结解剖骨髓甲状腺癌,甲状腺癌.倾向性得分匹配 (PSM) 是一种方法.阶段T1阶段T1 手术手术手术手术手术手术手术手术手术手术

更多相关视频

Gasless Endoscopic Thyroidectomy via the Trans-Axillary Approach

Gasless Endoscopic Thyroidectomy via the Trans-Axillary Approach

Published on: September 15, 2023

Transoral Robotic Total Thyroidectomy and Bilateral Central Regional Lymph Node Dissection for Papillary Thyroid Carcinoma

Transoral Robotic Total Thyroidectomy and Bilateral Central Regional Lymph Node Dissection for Papillary Thyroid Carcinoma

Published on: September 15, 2023

相关概念视频

The Thyroid Gland

The Thyroid Gland

The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...

Hyperthyroidism II: Pathophysiology

Hyperthyroidism II: Pathophysiology

Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH...