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影响患者服药合规性和视觉结果的因素 接受静脉内贝瓦西祖马布注射的患者
Ozukhil Radhakrishnan1, Tushar Agrawal1, Nilesh Giri1
1Ophthalmology, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Dr. D. Y. Patil Vidyapeeth (Deemed to be University), Pune, IND.
Cureus
|September 13, 2024
概括
内存贝瓦西祖马布治疗显示高服药性 (79.3%) 和显著的视觉改善对于眼睛疾病,如糖尿病视网膜病变. 年轻的患者,糖尿病持续时间较短,对治疗的坚持更好.
科学领域:
- 眼科医生 眼科 眼科
- 医学研究 医学研究
背景情况:
- 血管内皮生长因子 (VEGF) 驱动血管生成,但其过度活跃会导致眼睛疾病的病态新血管化.
- 糖尿病视网膜病变 (DR),与年龄相关的黄斑退化 (AMD) 和视网膜静脉封闭 (RVO) 是导致视力丧失的主要原因,具有重大全球影响.
研究的目的:
- 评估内贝瓦西祖马布治疗的成功率和视觉结果.
- 确定影响患者遵守和不遵守DR,新血管AMD和RVO治疗的因素.
主要方法:
- 一项实验性前后研究,涉及150名患有DR,新血管AMD或RVO的患者.
- 从2022年9月到2024年6月在三级医院收集的数据,使用SPSS与千平方和Pearson的相关性测试进行分析.
主要成果:
- 观察到的遵守率为79.3%,年轻患者和糖尿病持续时间较短的患者的遵守率更高.
- 治疗后观察到明显的视觉改善和黄斑厚度的减少.
- 财务负担,运输问题和后续行动的需要被确定为合规障碍.
结论:
- 内贝瓦西祖马布是有效的,四分之五的患者符合规定,并显示出显著的视觉效益.
- 解决诸如随访需求和患者支持等障碍,可以提高治疗坚持度.
- 建议进行进一步的随机对照试验,以比较对照组对治疗的有效性.
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