阻塞性睡眠呼吸暂停是否与更高的Covid-19严重程度有关?
Laíla Cândida Zacarias1, Danielle Mesquita Torres2, Samir Câmara Magalhães2,3
1Graduate Program in Cardiovascular Sciences, Universidade Federal do Ceará, Fortaleza, CE, Brazil.
Sleep science (Sao Paulo, Brazil)
|September 13, 2024
概括
由于COVID-19而住院的阻塞性睡眠呼吸暂停 (OSA) 患者经历了更严重的疾病. OSA与较低的氧气水平,增加对氧气治疗的需求,以及较高的血小板和D-二次体水平有关,这表明疾病的严重程度更高.
科学领域:
- 肺部医学 肺部医学
- 传染性疾病 传染性疾病
- 睡眠医学 睡眠医学
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 是一种常见的睡眠障碍.
- 冠状病毒疾病2019 (COVID-19) 是一个重要的全球健康问题.
- 需要进一步调查OSA和COVID-19严重程度之间的关系.
研究的目的:
- 检查住院患者中阻塞性睡眠呼吸暂停 (OSA) 和2019年冠状病毒疾病 (COVID-19) 的严重程度之间的关联.
- 确定与OSA患者的COVID-19严重程度相关的临床和实验室标记物.
主要方法:
- 研究了一组12名住院患有COVID-19的个人.
- 呼吸道多重检测用于诊断阻塞性睡眠呼吸暂停 (OSA).
- 患者被分为有 (OSA+) 和没有 (OSA-) 阻塞性睡眠呼吸暂停的组.
主要成果:
- 与OSA-组相比,OSA+组表现出明显较低的外周氧和度 (p=0.041).
- 在OSA+组 (100%) 和OSA-组 (28.57%) (p=0.013) 中,COVID-19的严重程度更高.
- OSA+患者需要更长时间的氧气治疗 (p=0.038) 并有血小板升高 (p=0.008) 和D-二次体水平 (p=0.019).
结论:
- 阻塞性睡眠呼吸暂停与住院患者COVID-19的严重程度增加有关.
- OSA与较差的氧化,延长的氧气治疗需求和高血栓标记物 (血小板,D-二次体) 相关联.
- 这些发现强调了在管理COVID-19患者时考虑OSA的重要性.
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