结核病诊断:转胺酶,十二指肠活检和遗传试验相关性相关性
Katia Regina Pena Schesquini-Roriz1,2, Gloria Maria Fraga Rodríguez2, Jocelyn Cristina Betancourt Castellanos2
1Department of Medicine, Federal University of Rondonia, Porto Velho, Brazil.
Frontiers in pediatrics
|September 13, 2024
概括
结核病的诊断与转谷氨酶 (TGA) 抗体水平与年龄和肠道活检结果相关. 较高的TGA水平与小儿乳病患者的肠缩和生长问题有关.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 遗传学 是一个遗传学.
背景情况:
- 乳病 (CD) 是一种自身免疫性疾病,在遗传敏感的个体中由质触发.
- 诊断依赖于人类白细胞抗原 (HLA) 单体类型DQ2/DQ8,转谷氨酸酶 (TGA) 抗体和肠道活检结果.
- 了解这些标志物之间的相关性有助于准确的诊断和管理.
研究的目的:
- 为了研究TGA抗体水平,HLA-DQ2/DQ8遗传标记物和肠道活检结果 (修改的马什分类) 在乳病诊断中的关系.
- 为了确定可能的相关性,可以完善胆固醇病的诊断方法.
主要方法:
- 对112名已确认患有乳病的患者进行了回顾性队列研究.
- 分析包括HLA-DQ2/DQ8测试,TGA抗体水平和肠道活检数据.
- 统计方法包括ANOVA,肯德尔相关性和线性回归.
主要成果:
- 在93%的患者中,HLA-DQ2呈阳性;在4.5%的患者中,DQ2/DQ8标志物呈阴性.
- TGA抗体水平与患者年龄呈反向相关性.
- 提升的TGA水平 (>1,000 U/ml) 与Marsh III (缩性) 活检结果和生长失败相关.
结论:
- 随着年龄的增长,TGA水平会降低,并且与肠缩和乳病的生长迟缓相关.
- HLA-DQ2/DQ8遗传测试在被诊断为患有乳病的患者中非常普遍.
- 这些相关性可以支持对乳病的诊断评估.
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