重用抗高血压药物治疗疼痛障碍:一种药物向的门德尔随机化研究
Kai Du1, Ao Li1, Chen-Yu Zhang1
1Graduate School, Beijing University of Chinese Medicine, Beijing, China.
Frontiers in pharmacology
|September 13, 2024
概括
抗高血压药物显示出在疼痛管理中重新利用的潜力. 一些课程可能会增加偏头痛的风险,而其他课程则有望减少四肢疼痛和其他疼痛障碍.
科学领域:
- 药物基因组学 药物基因组学
- 疼痛医学 医学 疼痛医学
- 心血管药理学心血管药理学
背景情况:
- 疼痛障碍的流行率不断上升,需要新的治疗策略.
- 目前的止痛药具有局限性,这促使人们寻找替代治疗方法.
- 高血压和疼痛共享潜在的生物联系,这表明潜在的药物重用.
研究的目的:
- 调查用于疼痛管理的抗高血压药物的重新用途的潜力.
- 使用孟德尔随机化 (MR) 方法,确定抗高血压药物标和疼痛障碍之间的因果关系.
主要方法:
- 使用DrugBank识别药物标,并从英国国家表单中编制抗高血压药物类别.
- 选择和验证单核酸多态 (SNP) 作为MR分析的遗传工具,不包括与冠状动脉疾病 (CAD) 相关的.
- 使用FinnGen R10数据库对29个与疼痛相关的结果进行孟德尔随机化 (MR) 分析,采用反变量加权 (IVW) 方法与邦费罗尼校正,并解决异质性和性.
主要成果:
- 强有力的证据将上腺神经元阻断剂与增加的偏头痛联系在一起,而没有光环风险,循环利尿剂与减少的胰腺炎有关.
- 血管扩展性抗高血压药物显示肢体疼痛风险降低,而有迹象表明,α-adrenoceptor阻断剂与偏头痛风险增加有关.
- 上腺神经元阻塞剂表明对关节骨关节炎的保护作用,增加女性肌痛的风险,以及其他各种抗高血压药物和疼痛条件的暗示联系.
结论:
- 抗高血压药物对疼痛障碍有多种影响,这表明它们具有重新定位的潜力.
- 需要进一步的研究来证实这些关联,并阐明最佳疼痛管理的潜在机制.
- 这些发现突显了心血管药物点和疼痛通路之间的复杂相互作用.
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