Pythium insidiosum:是一种新兴的病原体,很容易被误诊并被作为真菌治疗
Liuyang Hu1, Xiulu Huang2, Ngan Hung Yee3
1Department of Laboratory Medicine, The People's Hospital of Guangxi Zhuang Autonomous Region, Guangxi Academy of Medical Sciences, Nanning, China.
Frontiers in cellular and infection microbiology
|September 13, 2024
概括
皮蒂 (Pythium insidiosum) 引起皮蒂索斯 (Pythiosis),这是一个严重的感染,往往被误诊. 基因组测序和药物敏感性测试确定了有效的治疗方法,如线索利德和米诺环素,改善了患者的治疗结果.
科学领域:
- 医学真菌学 医学真菌学
- 传染性疾病 传染性疾病
- 基因组学就是基因组学.
背景情况:
- Pythium insidiosum是pythiosis的代理人,这是一个死亡率高,发病率增加的疾病.
- 由于医疗保健专业人员的认识有限,Pythiosis经常被误诊为真菌感染.
- 诊断和治疗pythiosis仍然具有挑战性,需要先进的诊断和治疗策略.
研究的目的:
- 报告两例皮索斯病例,包括角膜炎和皮肤形式.
- 调查元基因组下一代测序 (mNGS) 对于诊断pythiosis的有用性.
- 为了确定Pythium insidiosum的体外药物敏感性模式.
主要方法:
- 使用mNGS分析了两例pythiosis.
- 在试验室中诱导Pythium insidiosum动物体进行药物敏感性测试.
- 磁盘扩散和汁微稀释方法用于药物选.
主要成果:
- 在这两种情况下,mNGS成功地确定了Pythium insidiosum.
- 传统的抗真菌和抗菌药物没有显示出体外活性.
- 米诺环素,tigecycline,linezolid, erythromycin和azithromycin在体外表现出显著的活性.
结论:
- 通过mNGS和动物诱导进行准确和早期诊断至关重要.
- 药物敏感性测试指导有效的治疗选择pythiosis.
- 结合治疗新型抗生素,如linezolid和minocycline改善了患者的管理.
关键词:
在Pythium insidiosum中,Pythium被认为是最重要的.对抗微生物药物的敏感性.皮肤和皮肤下皮质症.这就是Pythiosis.皮索皮质炎 (Pythium keratitis) 是一种引起皮索皮质炎的疾病.更多相关视频
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