具有抗菌膜活性的抗生素 - 里芬素及其他抗生素
Luís Ferreira1, Ema Pos1, Daniela Rodrigues Nogueira1
1Department of Infectious Diseases, Centro Hospitalar e Universitário de Santo António, Porto, Portugal.
Frontiers in microbiology
|September 13, 2024
概括
管理假肢关节感染是复杂的细菌生物膜. 本综述强调了有效的抗菌膜药物和替代疗法,以对抗抗菌素耐药性并改善治疗结果.
科学领域:
- 整形外科 整形外科 整形外科
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 假肢关节感染 (PJI) 提出了复杂的管理挑战.
- 在外来物质上形成的细菌生物膜阻碍了抗生素的疗效.
- 抗菌素耐药性和治疗耐受性使PJI治疗复杂化.
研究的目的:
- 审查目前管理PJI的策略,重点关注抗菌膜活性.
- 突出有效的抗菌膜剂,并探索替代治疗方案.
- 解决对抗生物膜的强大和多样化的抗微生物选择的需求.
主要方法:
- 对假肢关节感染和生物膜管理研究的文献综述.
- 对具有抗菌膜活性药物的证据分析.
- 讨论传统疗法之外的替代治疗方法.
主要成果:
- 细菌生物膜通过创建保护矩阵,显著地使PJI治疗复杂化.
- 几种抗微生物药物表现出抗菌膜活性,尽管最佳使用需要定义.
- 抗菌素耐药性需要探索多样化和强效的治疗选择.
结论:
- 有效的PJI管理需要强大的抗菌膜策略.
- 强大而多样化的抗菌剂对于克服生物膜挑战至关重要.
- 与既定指南一起,应考虑替代治疗方案.
相关概念视频
Combined Effects of Drugs: Synergism
3.8K
Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
Such synergistic combinations...
3.8K
Antimicrobial Proteins
950
Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
950
Antibiotic Selection
52.4K
Overview
52.4K
Hand hygiene
3.1K
Asepsis is the practice of preventing or breaking the chain of infection. The nurse employs aseptic techniques to prevent the spread of microorganisms and reduce the risk of diseases. Hand hygiene is the cornerstone of aseptic techniques and is classified into medical and surgical asepsis. Medical asepsis includes hand hygiene and the use of gloves. Surgical asepsis, or the sterile technique, refers to practices that render and keep objects and areas free of microorganisms.
Hand washing...
Hand washing...
3.1K
Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents
111
Acute diarrhea, a common gastrointestinal disturbance, is characterized by the rapid evacuation of fluid stools, leading to an excessive weight in fluid. This condition typically arises from disorders affecting intestinal water and electrolyte transport. It can be triggered by an increased osmotic load within the intestine, excessive secretion of electrolytes and water, mucosal exudation of protein and fluid, or altered intestinal motility. The primary risks of acute diarrhea are dehydration...
111


