从基因组数据预测血型抗原的深度学习方法
Camous Moslemi1,2, Susanne Sækmose1, Rune Larsen1
1Department of Clinical Immunology, Zealand University Hospital, Køge, Denmark.
Transfusion
|September 13, 2024
概括
深度学习使用数组基因型定型准确预测血型,帮助识别罕见血型的捐赠者. 这种方法对大多数血型,甚至是复杂的血型都具有很高的准确性,提高了供体选择效率.
科学领域:
- 基因组学就是基因组学.
- 生物信息学是一种生物信息学.
- 计算生物学 计算生物学
背景情况:
- 深度学习正在改变自然科学.
- 选阵列基因型定型提供了具有成本效益和可扩展的数据.
- 这项研究探讨了血液型预测的深度学习.
研究的目的:
- 开发精确的血型预测模型.
- 使用选阵列基因型化数据.
- 利用深度学习技术.
主要方法:
- 结合血液银行数据与归算的基因型 (约111K丹麦,1168芬兰捐赠者).
- 采用深度学习:对缺失的基因型进行自动编码,然后使用卷积神经网络分类器.
- 在15个血型系统中预测了36个抗原.
主要成果:
- 超过三分之二的模型实现了>99%的F1精度.
- 对于大多数模型,即使对于具有挑战性的抗原 (例如Cw,Cob,RhD),也保持了高精度 (>97%).
- 绩效在独立的芬兰队列中得到验证.
结论:
- 使用数组基因型的基于深度学习的血型预测是非常可行的.
- 即使对具有复杂遗传基础的血型也有效.
- 通过预先选潜在的候选人,有助于识别罕见血型捐献者.
关键词:
在这里,我们可以看到AIAIAI.照明公司GSA照明公司血液中的抗原.血型是什么类型的 血型是什么类型的卷积神经网络是一种卷积神经网络.深度学习是一种深度学习.拒绝使用自动编码器.遗传预测 遗传预测更多相关视频
09:34A Virtual Machine Platform for Non-Computer Professionals for Using Deep Learning to Classify Biological Sequences of Metagenomic Data
Published on: September 25, 2021
3.9K
03:37Author Spotlight: Impact of Intergenic Interactions on Disease-Identifying Dark Biomarkers
Published on: March 1, 2024
658
相关概念视频
01:10Blood Typing
1.2K
Understanding an individual's blood group is a critical component of transfusion medicine. It ensures compatibility in blood transfusions, organ transplants, and even during pregnancy. Determining these blood groups involves the ABO and Rh blood typing systems, utilizing specific antigens and corresponding anti-sera to identify an individual's blood type.
Antigens are protein molecules that reside on the surface of red blood cells (RBCs). The ABO and Rh blood typing systems target...
Antigens are protein molecules that reside on the surface of red blood cells (RBCs). The ABO and Rh blood typing systems target...
1.2K
02:20Blood Types
17.5K
Human blood is classified into different types based on the presence of antigens on the red blood cell's surface and antibodies in the plasma. Proper identification of blood type is essential for successful blood transfusion. The International Society of Blood Transfusion has identified 38 human blood types based on the surface antigens on the red blood cells. The most common types are ABO, Rh, and MNS blood types.
ABO blood group
ABO antigens are glycoproteins encoded by genes present on...
ABO blood group
ABO antigens are glycoproteins encoded by genes present on...
17.5K
02:45Blood Transfusion and Agglutination
10.8K
Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
10.8K
01:11Genome-wide Association Studies-GWAS
13.2K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
13.2K
01:19Rh Blood Group
1.4K
The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.
1.4K