在阿尔茨海默氏病中,RTP801与tRNA结合酶复合体相互作用,并对其RNA结合酶活性进行失调

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Genís Campoy-Campos1,2, Julia Solana-Balaguer1,2, Anna Guisado-Corcoll1,2,3

  • 1Departament de Biomedicina, Institut de Neurociències, Universitat de Barcelona, Barcelona 08036, Catalonia, Spain.

Nucleic acids research
|September 13, 2024
PubMed
概括

升高的RTP801/REDD1蛋白质会损害阿尔茨海默病 (AD) 中的RNA处理. 沉默RTP801恢复RNA处理并防止神经元异常,这表明RTP801抑制是潜在的AD疗法.

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