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抗菌电膜与等级珠串结构纤维用于伤口感染

Yu Xuan Fong¹, Catherine Pakrath¹, Fathima Shana Pattar Kadavan¹

¹College of Medicine and Public Health, Flinders University, Bedford Park, Adelaide, SA 5042, Australia.

Nanomaterials (Basel, Switzerland)

|September 13, 2024

概括

这项研究开发了用于慢性伤口感染的先进的,含有西普罗夫洛克萨的多罗拉克-丝纳米纤维. 这种新型纳米纤维具有强大的抗菌活性和良好的生物相容性,为受感染的伤口提供了有前途的新疗法.

科学领域:

生物材料科学生物材料科学
纳米技术纳米技术
伤口愈合治愈伤口愈合

背景情况:

慢性伤口由于持续的感染和排泄物管理问题,给医疗保健带来了重大挑战.
电药物纳米纤维正在成为感染慢性伤口的先进局部治疗方法.

研究的目的:

为了优化电旋转参数,以生产含有齐普罗夫洛克萨的多罗拉克-丝 (PCL/SS-PVA-CIP) 纳米纤维.
评估开发的PCL/SS-PVA-CIP纳米复合材料的抗菌疗效,生物相容性和药物释放特征.

主要方法:

使用电技术制造PCL/SS-PVA-CIP纳米纤维.
对*P. aeruginosa*和*S. aureus*进行抗菌活性评估.
在体外生物相容性使用HaCaT和HGF细胞系进行了评估.
药物释放动力学在72小时内进行了研究.

主要成果:

PCL/SS-PVA-CIP纳米复合材料在特定度 (3μg/g和7.0μg/g,分别) 中表现出强大的抗菌活性,对抗P. aeruginosa和S. aureus.
纳米复合材料与HaCaT和HGF细胞具有良好的细胞兼容性,即使在较高的抗生素剂量下也支持细胞增殖.
在72小时后,对于各自的有效度,观察到最大累积药物释放率为76.5%和74.4%.

结论:

优化的PCL/SS-PVA-CIP纳米纤维显示出作为慢性伤口管理的有效抗菌伤口带的巨大潜力.
在纳米纤维格式中将丝素和聚烯酸与西普罗夫洛克萨结合起来,为治疗复杂的伤口感染提供了一个有希望的策略.

关键词:

生物相容性的生物相容性可生物降解,可生物降解.这就是西普罗夫洛克萨辛 (Ciprofloxacin).纳米纤维是一种纳米纤维.自然聚合物的天然聚合物.聚卡普罗拉克托尼是一种多重的产物.丝丝丝丝

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