和皮肤微生物组:对治疗机制和影响的系统审查
Alicia Podwojniak1, Isabella J Tan2, John Sauer1
1Rowan-Virtua School of Osteopathic Medicine, Stratford, New Jersey, USA.
Journal of the European Academy of Dermatology and Venereology : JEADV
|September 13, 2024
概括
这篇评论探讨了和皮肤微生物之间的联系,发现像氧化这样的治疗改变了微生物多样性. 未来的疗法可能将重点放在微生物组调制上,以实现个性化治疗.
科学领域:
- 皮肤病学 皮肤病学
- 微生物学 微生物学
- 基因组学就是基因组学.
背景情况:
- 是一种常见的皮肤疾病,由脂质单元的炎症驱动.
- 的发展涉及皮肤生理学和皮肤微生物群之间的复杂相互作用.
- 现有的治疗方法有局限性,这引发了人们对基于微生物的治疗策略的兴趣.
研究的目的:
- 为了研究和皮肤微生物组之间的关系.
- 评估当前治疗对皮肤微生物群体的影响.
- 探索潜在的新疗法,以皮肤微生物群为管理的目标.
主要方法:
- 对过去10年内发表的研究进行了系统审查.
- 在PubMed和SCOPUS上进行了搜索,在对1830个记录进行初步选后,产生了26篇相关文章.
- 对α多样性变化的元分析使用不同治疗组的固定和随机效应模型进行.
主要成果:
- 在中涉及的关键细菌包括Cutibacterium acnes, Staphylococcus aureus和Staphylococcus epidermidis,通过过度增殖或失能症等机制.
- 目前的治疗方法,如多西环素,过氧化物 (BPO),异二烯,硫胺-硫 (SSA) 和氨基酸光动力学疗法 (ALA-PDT),被发现可以调节皮肤微生物组.
- 氧化是元分析中发现的唯一一种治疗方法,可以显著改变微生物多样性.
- 新兴疗法包括局部益生菌,植物衍生品和蛋白质衍生品,以解决失生症和炎症.
结论:
- 该研究强调了微生物组在病原发生中的复杂作用,尽管研究设计和分类方法存在差异.
- 治疗药物显然会影响微生物的多样性,丰富性和组成.
- 基于微生物组调节的个性化管理策略是必不可少的.
相关概念视频
01:23Skin Diseases and Disorders
3.7K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
3.7K
01:26Factors Affecting the Risk of Infection
11.5K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
11.5K
01:31Defense Against Bacterial Pathogens
1.4K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
1.4K