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Author Spotlight: Exploring the Role of Unfolded Protein Response in HIV-1 Replication and Infectivity
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艾滋病毒-1 Vpr诱导的DNA损伤通过ATM-NEMO独立于细胞周期停止激活NF-κB

Carina Sandoval1, Karly Nisson1, Oliver I Fregoso1,2

  • 1Molecular Biology Institute, University of California, Los Angeles, California, USA.

mBio
|September 13, 2024
PubMed
概括

艾滋病毒辅助蛋白Vpr引发DNA损伤,激活ATM-NEMO通路和NF-κB转录. 这一过程对于病毒复制至关重要,它独立于细胞循环停止,甚至发生在感染的早期.

关键词:
造成的DNA损伤是DNA损伤.在 NF-kBB 中.这就是Vpr Vpr.主机响应的主机响应.人类免疫缺陷病毒人类免疫缺陷病毒巨细胞是什么?巨细胞是什么?转录因子是一种转录因子.病毒与宿主之间的相互作用

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