[与西尼罗河病毒相关的Opsoclonus-myoclonus综合征]
A Yu Kazantsev1,2, I V Nikolaeva1,2, B Sh Fatkullin2
1Kazan State Medical University, Kazan, Russia.
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova
|September 13, 2024
概括
西尼罗河热可以导致克隆-肌克隆综合征,这是一个罕见的神经系统疾病. 早期诊断和治疗对于从这种病毒性脑炎中恢复至关重要.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 眼科医生 眼科 眼科
背景情况:
- 奥普索克隆斯是一种罕见的眼动运动障碍,其特点是不自发的,混乱的眼动.
- 奥普索克隆斯-肌克隆斯综合征通常是由瘤性过程引起的,但可以具有病毒性病因.
- 西尼罗河病毒 (WNV) 是一种潜在的,虽然不太常见的,神经侵入性疾病的原因.
研究的目的:
- 为了呈现一种由西尼罗河热引起的克隆-肌克隆综合征病例.
- 突出考虑WNV在无法解释的奥普索克隆-肌综合征的差异诊断中的重要性.
- 为了强调西尼罗河病毒的神经侵入性潜力.
主要方法:
- 一个26岁的男性出现脑炎症状的病例报告.
- 神经学检查显示了克隆,肌克隆和严重的动力衰竭.
- 脑脊液分析,脑部MRI和西尼罗河病毒的血清学/PCR检测.
主要成果:
- 患者在发烧性疾病后表现出克隆,肌克隆和动力衰竭.
- 大脑脊髓液显示有多细胞形成和蛋白质升高.
- 通过增加WNV IgG/IgM标位和CSF中阳性WNV RNA PCR证实了诊断.
- 尽管初始治疗,神经症状持续了两周,但在康复后得到解决.
结论:
- 神经侵入性西尼罗河热可以表现为克隆-肌克隆综合征.
- 在opsoclonus-myoclonus综合征的病因学中应考虑WNV,特别是在特有地区.
- 及时诊断和支持性护理,包括康复,对于患者的康复至关重要.
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