草药杀虫剂索尔比基类类似物会导致在Aspergillus aculeatus TE-65L中积聚红素
Xin-Rong Huang1,2, Chao-Nan Jiang1, Hai-Su Wang1
1Tobacco Research Institute of Chinese Academy of Agricultural Sciences, Qingdao 266101, China.
Journal of agricultural and food chemistry
|September 13, 2024
概括
研究人员发现了新的天然除草剂从真菌Aspergillus aculeatus. 这些类药物对杂草生长表现出强烈的活性,为合成除草剂 (如草甘) 提供了有希望的替代品.
科学领域:
- 自然产品化学 自然产品化学
- 菌类学 菌类学是指菌类学.
- 农业科学 农业科学
背景情况:
- 内生真菌,如Aspergillus aculeatus,是生物活性化合物的丰富来源.
- 索尔比塞利诺酸是一种具有多样化的生物活动的真菌代谢物.
- 新型天然除草剂的开发对于可持续农业至关重要.
研究的目的:
- 从*Aspergillus aculeatus* TE-65L中分离和表征新的基类衍生物.
- 评估这些化合物对各种杂草物种的除草剂活性.
- 阐明最活跃化合物的作用机制.
主要方法:
- 使用色谱技术分离和净化真菌代谢物.
- 通过全面的光谱分析 (NMR,MS) 和电子循环二元化 (ECD) 计算来阐明结构.
- 生物测试以确定除草剂活性 (细菌和根茎延长抑制) 和机理学研究 (转录组学,LC-MS/MS,传输电子显微镜).
主要成果:
- 分离了五种新的类药物,包括 (±) - 类药物A (1) 和类药物B-D (2-4),以及两种已知的类似物 (5-6).
- 化合物1显著抑制了Eleusine indica*胚芽延伸 (IC50 = 28.8 μg/mL),而化合物6抑制了根茎延伸 (IC50 = 25.6 μg/mL),表现优于草甘.
- 化合物6诱导了素生物合成,导致细胞壁加厚和抑制杂草生长.
结论:
- 来自*Aspergillus aculeatus*的新型菌素衍生物具有强大的除草剂特性.
- 这些天然化合物为合成除草剂提供了可行的替代品.
- 这些发现扩大了sorbicillinoids的农业应用,并为天然除草剂开发提供了化合物.
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