相关实验视频
Updated: Jun 13, 2025
08:40
Chronic Salmonella Infection Induced Intestinal Fibrosis
Published on: September 22, 2019
7.0K
难以治疗的炎症性肠病的流行,特征,管理和结果
Tommaso Lorenzo Parigi1,2, Luca Massimino1, Alfredo Carini2
1IBD Unit, Department of Gastroenterology, IRCCS Ospedale San Raffaele, Milan, Italy.
Journal of Crohn's & colitis
|September 13, 2024
概括
难以治疗的炎症性肠病 (DTT-IBD) 影响了近四分之一的患者,特定的疾病特征增加了风险. 在DTT-IBD患者中,结果较差,药物的有效性随着每一条治疗线路的减少而下降.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 内部医学 内部医学
背景情况:
- 炎症性肠病 (IBD) 包括克罗恩氏病和性结肠炎.
- 最近,针对"难以治疗"的炎症性肠病 (DTT-IBD) 提出了标准化标准.
- 了解DTT-IBD患病率和特征对于优化患者管理至关重要.
研究的目的:
- 在现实环境中评估DTT-IBD的患病率.
- 确定与DTT-IBD相关的风险因素和特定现象.
- 评估与非DTT-IBD患者相比,DTT-IBD患者的管理和结果.
主要方法:
- 在意大利的两个三级护理中心进行的回顾性研究.
- 对1736名IBD患者的分析,这些患者接受了生物药物或先进的小分子治疗.
- 评估DTT-IBD标准,患者特征,治疗策略和缓解率.
主要成果:
- 大约24.8%的IBD患者符合DTT-IBD标准,其中77%的患者至少失败了两个作用机制.
- 特定的性结肠炎表型 (左侧和扩展性结肠炎) 和克罗恩病行为 (紧缩,透,围疾病) 是DTT-IBD的重要风险因素.
- 与非DTT-IBD患者相比,DTT-IBD患者的症状,生化和内镜缓解率较低,内镜缓解率明显较低 (25%对62%).
结论:
- DTT-IBD是大约四分之一的IBD患者在三级护理机构中的普遍疾病.
- 某些IBD表型和克罗恩病中延迟开始治疗被确定为DTT-IBD的危险因素.
- 药物持久性随着克罗恩病和性结肠炎的每一项后续治疗逐渐减少.
更多相关视频
相关概念视频
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
324
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
324
01:29Inflammatory Bowel Disease IV: Pharmacological Management
118
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
118
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
153
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
153
01:30Inflammatory Bowel Disease II: Crohn's Disease
201
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
201
01:17Chronic Bowel Disorders: Introduction
410
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
410
01:21Inflammatory Bowel Disease V: Surgical Management
128
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Here are some common surgical interventions for IBD:
128