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作为一种新的铁补充剂,Enteromorpha prolifera多糖体-Fe (III) 复合物促进肠道发育

Yingying Feng¹, Yuying Wu¹, Jialu Wang¹

¹Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China.

Science China. Life sciences

|September 13, 2024

概括

在新生儿的饮食中,Enteromorpha prolifera多糖体-Fe (III) 复合物 (EP-Fe) 有效地提高了新生儿的铁水平. 这种新的铁补充剂促进肠道发育,增强肠道健康,改善婴儿营养.

科学领域:

营养科学营养科学
生物化学生物化学
胃肠病学胃肠病学

背景情况:

缺铁会给婴儿带来很大的健康风险.
饮食中的多糖体-铁 (III) 复合物 (PICs) 提供了一个有前途的解决方案,因为吸收率高,副作用低.

研究的目的:

为了评估Enteromorpha prolifera多糖体-Fe (III) 复合物 (EP-Fe) 作为新生儿铁补充剂的疗效.
研究EP-Fe对肠道发育,细胞对缺氧的反应,粘膜屏障功能和肠道微生物群的影响.

主要方法:

利用3天的断奶小猪模型来模拟新生儿的铁缺乏症.
采用转录组测序来分析对EP-Fe.Fe.反应的基因表达变化.
进行了16S rRNA基因测序,以评估EP-Fe对肠道微生物群组成的影响.

主要成果:

补充EP-Fe显著改善了铁含量,并促进了小猪的肠道发育.
EP-Fe上调调节了支持血管系统发育的基因,增强了缺氧下肠道上皮细胞的存活率.
通过抑制MLCK/p-MLC通路,EP-Fe增强了粘膜屏障,增加了紧结蛋白的表达.
EP-Fe促进了有益的肠道微生物如 Bacteroides_fragilis 的丰富性,这些微生物以碳水化合物代谢而闻名.

结论:

EP-Fe作为新生儿的有效铁补充剂,证明了对肠道健康的多方面的益处.
EP-Fe有可能发展成为婴儿健康和发育的综合营养补充剂.

关键词:

类植物多种多糖体-Fe (III) 复合体.我们的肠道微生物群.肠道的发育肠道的发育缺铁症是因为缺铁.断奶的小猪断奶的小猪

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