在65岁以上的老年患者中,基于FAERS的诺基诺药物的安全性分析
Yanwei Li1, Li Chen2,3, Xiting Tang1
1Department of Pharmacy, People's Hospital of Ganzi Tibetan Autonomous Prefecture, Kangding, Sichuan, China.
Expert opinion on drug safety
|September 13, 2024
概括
老年人中诺 (FQs) 的不良药物事件 (ADEs) 根据药物而异. 莫西弗洛克萨可能导致心脏和精神问题,而西普洛克萨和莱沃弗洛克萨会影响肌肉骨健康. 使用莫西弗洛克萨和奥洛克萨时,眼部风险更高.
科学领域:
- 药物监督 药物监督 药物监督
- 老年医学 老年医学
- 药品安全 药品安全
背景情况:
- 诺基诺 (FQs) 已被广泛处方,但它们在老年患者 (≥65岁) 的不良药物事件 (ADE) 概况需要详细调查.
- FAERS数据库为分析真实世界的ADE报告提供了宝贵的资源.
研究的目的:
- 在65岁及以上的患者中调查与特定FQ药物相关的ADEs.
- 在老年人群中合理临床使用FQ的信息.
主要方法:
- 使用报告几率比率 (ROR) 和比例报告比率 (PRR) 方法.
- 从2015年第一季度到2023年第四季度 (36个季度) 分析了西普罗夫洛克萨,莱沃弗洛克萨,莫西弗洛克萨和奥洛克萨的ADE报告.
主要成果:
- 鉴定了6883例西普洛素的ADE病例,5866例莱沃素的ADE病例,1498例莫西素的ADE病例,以及317例奥洛素的ADE病例.
- 莫西弗洛克萨辛在心脏 (4.01%) 和精神疾病 (23.11%) 中显示了较高的ADE率.
- 与莫西弗洛克萨 (3.62%) 和奥洛克萨 (9.25%) 相比,西普罗夫洛克萨和莱沃弗洛克萨的肌肉骨ADE率较高 (20.18%,26.97%).
- 莫西弗洛克萨辛和奥洛克萨辛在眼睛疾病中增加了ADE率 (10.61%,15.03%).
结论:
- 不同的FQ具有不同的ADE概况,影响老年患者的各种器官系统.
- 患有并发症的患者应避免与其特定疾病相关的高风险相关的FQ.
- 个性化药物治疗策略对于优化老年患者的FQ使用至关重要.
关键词:
美国食品和药物管理局的不良事件报告系统 (FAERS)65岁以上的老年患者.诺基诺 (FQs) 是一种相对报告比率 (PRR) 是指比例报告比率.报告几率比率 (ROR) 的报告几率比率.安全监督安全监督安全监督更多相关视频
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