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Updated: May 2, 2026

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一个1024通道的同时电生理学和电化学神经记录系统,具有像素内数字化和交叉声补偿
IEEE transactions on biomedical circuits and systems
|September 13, 2024
概括
这项研究介绍了一种1024通道的CMOS实验室系统,用于同时进行神经记录. 新型设计抑制干扰,使得高分辨率的电生理学和电化学数据采集成为可能.
科学领域:
- 神经科学是一个神经科学.
- 电气工程 电气工程
- 材料科学 材料科学 材料科学
背景情况:
- 同时的电生理和化学记录提供了多模式的神经洞察力.
- 模间干扰限制同步,高分辨率的神经记录系统.
研究的目的:
- 开发一种1024通道的CMOS实验室系统,用于双模态神经记录.
- 解决大规模神经仪器仪表中的交联干扰问题.
主要方法:
- 实现了像素内数字化和干扰抑制.
- 使用前景校准方案,可调节电容,用于交叉通话补偿.
- 设计的活跃像素具有脉冲宽度调制 (PWM) 模拟到数字转换,用于电气和化学模式.
主要成果:
- 开发了一个33毫米2的原型,使用180纳米CMOS技术与1024像素.
- 每个像素都有一个电气和两个化学记录站点 (150μm × 130μm).
- 实现了低功耗 (19.68mW),并证明了同时进行高密度电生理学和电化学记录,具有次毫秒时间分辨率.
结论:
- 实验室对CMOS系统成功实现了同时进行高密度神经记录.
- 在像素内干扰抑制和校准对于双模态神经仪器有效.
- 该技术为研究神经活动提供了强大的工具,具有增强的时间和空间分辨率.
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