过敏原免疫疗法和埃索诺菲尔性食道炎:朋友还是敌人?
Constantinos Pitsios1,2, Carlo Maria Rossi3,4
1Medical School, University of Cyprus.
Current opinion in allergy and clinical immunology
|September 13, 2024
概括
性食道炎 (EoE) 与过敏原免疫疗法有着复杂的联系. 虽然口服免疫疗法 (OIT) 可以引起EoE,但其他形式如皮下免疫疗法可能是有益的,指导未来的EoE管理策略.
科学领域:
- 免疫学 免疫学 免疫学
- 过敏 过敏是一种过敏.
- 胃肠病学 胃肠病学
背景情况:
- 性食道炎 (EoE) 的爆发通常是由过敏原暴露引起的,主要是食物过敏原.
- 过敏原免疫疗法和EoE发展之间的关系是复杂的,并且根据治疗类型而异.
研究的目的:
- 审查埃索诺菲尔性食道炎 (EoE) 与各种形式的过敏原免疫治疗之间的复杂联系.
- 探索食物和空气中的过敏原在EoE爆发和免疫疗法诱导的EoE中的作用.
主要方法:
- 关于过敏原免疫疗法的当前文献综述,以及其与乙酸性食道炎的关联.
- 分析了动物模型的发现,研究了空气过敏原敏感化和EoE之间的联系.
- 检查与EoE相关的不同免疫疗法 (OIT,SLIT,SCIT,EPIT) 报告的病例和结果.
主要成果:
- 口服免疫疗法 (OIT) 被认为是EoE的常见原因,而舌下免疫疗法 (SLIT) 的相关性不太清楚.
- 动物模型表明,在空气过敏原敏感化后,EoE发育中存在遗传成分.
- 皮下过敏原免疫疗法 (SCIT) 没有显示对EoE的致病作用和潜在的有益影响.
- 皮肤上免疫疗法 (EPIT) 已被用于治疗儿童的牛奶诱导的EoE.
结论:
- 了解过敏原和EoE之间的免疫联系对于优化过敏原免疫疗法至关重要.
- 这些见解可以为EoE管理的未来策略提供信息,可能导致更安全,更有效的治疗方法.
相关概念视频
02:06Allergic Reactions
27.3K
Overview
27.3K
01:25Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
246
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
246
01:26Asthma-II: Pathophysiology and Classification
2.6K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
2.6K
01:20Asthma: Pathogenesis and Management
371
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
371
00:42Cross-reactivity
31.0K
Overview
31.0K
01:27Allergic Drug Reactions
821
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
821