在Idiopathic REM睡眠行为障碍中的IGLON5频率:一个多中心研究
Ronald Postuma1, Nisa Vorasoot1, Erik K St Louis1
1From the Montreal Neurological Institute and Department of Neurology and Neurosurgery (R.P.), Montréal, McGill University; Center for Advanced Research in Sleep Medicine (R.P., A.P., J.-F.G.), Hôpital du Sacré-Coeur de Montréal; Research Institute of the McGill University Health Centre (R.P., A.P., Z.G.-O.), Montreal, Quebec, Canada; Neurology and Medicine (N.V., L.K.F., J.A.F., O.A.R., W.S., B.F.B., A.M.), Mayo Clinic, Rochester, MN; Division of Neurology (N.V., E.K.S.L.), Department of Medicine, Faculty of Medicine, Khon Kaen University, Thailand; Department of Neurology (M.M.L., J.E.), Oregon Health & Science University; Department of Behavioral Neuroscience (M.M.L.); Department of Pulmonary and Critical Care Medicine; Oregon Institute of Occupational Health Sciences; Mental Illness Research Education and Clinical Center (M.M.L.); Neurology; National Center for Rehabilitative Auditory Research; Research Service (M.M.L., J.E.), VA Portland Health Care System, OR; Département of Psychology (J.-F.G.), Université du Québec à Montréal; Department of Human Genetics (Z.G.-O.), McGill University, Montréal, Québec, Canada; Neurology (D.E.H., D.L.B.), Emory University, Atlanta, GA; Neurology (A.Y.A.), Sleep Disorders Center, University of California, Los Angeles; Minnesota Regional Sleep Disorders Center (M.H., C.H.S.), and Departments of Psychiatry, Hennepin County Medical Center, and University of Minnesota Medical School; Minnesota Regional Sleep Disorders Center (M.H.), Hennepin County Medical Center, Minneapolis, MN; Washington University School of Medicine (J.M., A.A.D., Y.-E.S.J.), Saint Louis, MO; Barrow Neurological Institute (S.R.C.), Phoenix, AZ; Movement Disorders Unit (A.V.), Division of Sleep Medicine, Massachusetts General Hospital; Neurological Clinical Research Institute (A.V.), Harvard Medical School, Boston, MA; Psychiatry and Behavioral Sciences (E.H.D., M.G.M.), Stanford University, Redwood City, CA; Neurology and Neurological Sciences (E.H.D., M.G.M.), Stanford University, Palo Alto, CA; and Neurology (E.H.D.), Mt. Sinai School of Medicine, New York.
近1%的患有异常REM睡眠行为障碍 (iRBD) 个体的IGLON5自身抗体检测结果呈阳性,这表明与可治疗的自身免疫性疾病的联系. 这一发现对诊断和管理iRBD患者具有重大临床影响.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
背景情况:
- 异常性REM睡眠行为障碍 (iRBD) 通常与像帕金森氏症这样的神经退行性疾病有关.
- 越来越多的证据表明,RBD也可能是可治疗的自身免疫性疾病的早期迹象,例如IGLON5综合征.
研究的目的:
- 在被诊断为iRBD的大量患者中确定特定自身抗体的频率.
- 评估自身免疫性疾病的潜力,呈现为iRBD.
主要方法:
- 包括339名患有多睡眠学证实的iRBD,没有帕金森症或痴呆症的参与者.
- 血样本被查IGLON5,DPPX,LGI1和CASPR2自身抗体使用基于细胞的测试.
- 通过重复测试和基于组织的IGLON5.5免疫光测试,证实了积极或模两可的结果.
主要成果:
- 三名参与者 (0.9%) 显示出已确认的IGLON5自身抗体.
- 另外一个参与者有一个低位数的CASPR2自身抗体.
- 阳性病例中的症状包括梦想演变,认知衰退,自主功能障碍和运动症状.
结论:
- 大约1%的iRBD患者可能患有严重的,可能可治疗的自身免疫综合征.
- 常规的自身抗体测试,特别是IGLON5-IgG,在iRBD诊断中需要考虑.
- 衡量测试成本,效益和潜在的假阳性效应对于实施至关重要.
相关概念视频
REM Sleep Behavior Disorder
RBD is significantly associated with...
Restless Leg Syndrome and Night Terrors
The exact cause of RLS is not fully understood, but it is believed to involve dopamine, a neurotransmitter that helps regulate muscle movement. Imbalances in dopamine levels...
Sleep-Wake Cycles
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
Narcolepsy
Sleepwalking and Sleep Talking
Factors that increase the likelihood of sleepwalking include sleep deprivation and alcohol consumption. Contrary to common beliefs, it is safe...
Stages of Sleep
Before sleep begins, in wakefulness, the brain exhibits primarily beta waves, which are high in frequency and low in amplitude, indicating alertness...


