狄克洛菲纳克的转化产品:水生环境中的形成,发生和毒性影响
Katarzyna Nosek1, Dongye Zhao2
1Department of Fuels Technology, Faculty of Energy and Fuels, AGH University of Krakow, Al. A. Mickiewicza 30, Krakow 30-059, Poland.
Water research
|September 13, 2024
概括
迪克洛菲纳克转化产品 (TPs) 在废水和地表水中普遍存在,往往超过原始药物度. 这些TP带来了重大环境风险,需要更新风险评估.
科学领域:
- 环境化学环境化学
- 生态毒理学 生态毒理学
- 药品在环境中的作用
背景情况:
- 狄克洛菲纳克 (DCF) 是一种优先物质,因为它在废水处理中广泛使用和不完全清除.
- DCF转化产物 (TP) 和代谢物往往比DCF更有毒,并且在废水中占主导地位.
- 这些TP在环境风险评估中基本上被忽视了.
研究的目的:
- 批判性地审查最近关于DCF TPs在水环境中的形成,发生,命运和毒理学的数据.
- 突出DCF代谢物的环境意义及其对整体药物毒性的贡献.
- 评估目前药品风险评估实践的充分性.
主要方法:
- 对Diclofenac转化产品的最新数据的文献综述.
- 对DCF TPs的形成,发生,环境命运和毒理学的分析.
- 检查废水处理厂 (WWTP) 在去除DCF及其TP时的效率.
主要成果:
- 在废水流入 (> 57%),废水 (~ 60%) 和地表水 (~ 30%) 中,DCF TPs占DCF的很大一部分.
- TPs保留了DCF的核心结构,可能比原始药物带来更大的环境风险.
- 污染物是DCF及其副产品的一致来源;与其他污染物的混合物可能会导致协同作用的风险.
结论:
- 目前的风险评估可能低估了DCF的环境毒性,因为它忽略了代谢物和协同效应.
- 代谢物可以恢复到DCF,导致持续的环境污染.
- 需要进一步研究长期代谢物命运,毒性以及改进的分析方法来识别隐藏的风险.
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