微塑料和纳米塑料检测测试验的进展:为生物监测和暴露学研究铺平了道路
Kuanliang Shao1, Runyu Zou2,3, Zhuoyue Zhang1
1Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA;
Annual review of pharmacology and toxicology
|September 13, 2024
概括
微型和纳米塑料 (MNP) 的健康风险是未知的,尽管它们存在于人体组织中. 需要标准化生物监测来评估MNP暴露和潜在的健康影响.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 分析化学 分析化学
背景情况:
- 微塑料和纳米塑料 (MNP) 是普遍存在的环境污染物.
- 新出现的证据表明,MNP可以在人类生物流体和组织中检测到.
- 关于人类暴露水平和相关的健康风险,存在重大知识差距.
研究的目的:
- 审查目前测量MNP和人类相关化学物质的方法.
- 探索MNP暴露的全人口生物监测方法.
- 突出了对标准化分析方案和综合生物反应措施的需求.
主要方法:
- 对人类样本中MNP检测现有分析技术的审查.
- 对评估暴露在与塑料相关的化学品中的方法的评估.
- 讨论当前生物监测策略中的挑战.
主要成果:
- 目前对人类MNP的暴露评估是有限的.
- 超过1万种化学物质与塑料制造有关,使暴露分析复杂化.
- 分析技术的进步已经存在,但缺乏标准化的协议.
结论:
- 对于MNP生物监测来说,需要标准化,高通量方法.
- 将MNP测量与生物反应数据的整合对于理解健康影响至关重要.
- 需要加强研究,以评估和减轻MNP对公共卫生的影响.
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