2019年慢性冠状病毒病的持续性和恢复的决定因素 化学感官功能障碍 2019年慢性冠状病毒病的持续性和恢复的决定因素
Dante G Minichetti1, Amelia Boyd1, Evan Lemire2
1Division of Allergy and Clinical Immunology, Jeff and Penny Vinik Center for Allergic Disease Research, Brigham and Women's Hospital and Department of Medicine, Harvard Medical School, Boston, Mass.
The Journal of allergy and clinical immunology
|September 13, 2024
概括
在COVID-19 (冠状病毒疾病2019) 后,持续的嗅觉和味觉丧失是常见的,过敏和高血压预测恢复. 香烟烟雾预测持续的功能障碍,治疗仍然在很大程度上对慢性化学感官功能障碍 (CSD) 无效.
科学领域:
- 神经学 神经学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 传染性疾病 传染性疾病
背景情况:
- 很大一部分COVID-19患者经历了超过六个月的持续性化学感官功能障碍 (CSD).
- 这种慢性疾病影响着数百万人,需要对其预测因素和恢复模式进行研究.
研究的目的:
- 为了确定从COVID-19相关的CSD中恢复的预测因素.
- 评价持续嗅觉和味觉丧失的患者中CSD的质量.
主要方法:
- 一组408名COVID-19 CSD患者在四个时间点 (2021-2023) 填写了问卷.
- 评估了人口统计,鼻症状和康复情况.
- 对108名参与者进行了客观嗅觉 (UPSIT) 和味觉 (BWETT) 测试.
主要成果:
- 平均症状持续时间为24个月;70%的2020年COVID-19病例报告持续的功能障碍.
- 幻影症和幻症是常见的早期症状;受损的气味 / 味道区分和波浪功能是普遍存在的.
- 环境过敏和高血压预测恢复,而香烟烟雾预测持久性. 鼻腔类固醇在康复的患者中显示出一些疗效.
结论:
- 慢性COVID-19 CSD对标准的抗炎疗法具有抗性.
- 环境过敏和高血压等先前存在的疾病是恢复的积极预测因素.
- 特定的嗅觉幻觉,如香烟烟雾幻觉症,与持续的CSD有关.
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