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自闭症谱系障碍儿童中的差异性单碳代谢物:一个案例对照研究

Tianqi Wang¹, Wennan He², Yun Chen³

¹Department of Neurology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.

The Journal of nutrition

|September 13, 2024

概括

自闭症谱系障碍 (ASD) 与改变的单碳代谢 (OCM) 有关. 患有ASD的儿童在OCM代谢物中表现出显著的差异,这表明ASD的潜在治疗点.

科学领域:

生物化学生物化学
神经科学是一个神经科学.
代谢学代谢学代谢学

背景情况:

自闭症谱系障碍 (ASD) 有一个复杂的,多因素的病因.
叶酸依赖的单碳代谢 (OCM) 障碍越来越多地与ASD病理有关,尽管证据仍然不确定.

研究的目的:

调查OCM代谢与儿童ASD之间的关联.
在被诊断为ASD的儿童中识别和描述差异性OCM代谢物.

主要方法:

在59名ASD儿童和40名神经类型儿童中研究了血OCM代谢物.
使用了超高性能液态色谱学双重质谱法 (UPLC-MS/MS).
分析了OCM代谢物的差异,并使用多变量模型对共变量进行调整.

主要成果:

22种OCM代谢物中的10种在ASD儿童和对照儿童之间有显著差异.
在ASD中观察到的S-adenosylmethionine (SAM) 和glutathione (GSH) 的水平升高;S-adenosylhomocysteine (SAH),胆,甘氨酸,L-serine,cystathionine,L-cysteine和 taurine的水平降低.
与对照组相比,患有自闭症儿童的SAM/SAH比率更高,GSH/GSSG比率更低.

结论:

在ASD儿童中观察到OCM障碍,特别是影响 metionin甲基化和转硫化通路.
研究结果提供了对ASD机制的见解,并建议OCM调制作为潜在的治疗策略.
这些有希望的发现需要进一步验证.

关键词:

自闭症谱系障碍自闭症谱系障碍胃肠道症状胃肠道症状甲胺甲基化的甲胺甲基化一个碳代谢的一个碳代谢.通过硫化转化.

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相关概念视频

Autism Spectrum Disorder

Autism Spectrum Disorder

Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.