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精神障碍和脑血管疾病之间的因果关系:来自孟德尔随机化研究的证据

Wenwen Xiang¹, Yu Shen², Yanping Li³

¹Department of Neurology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.

Journal of affective disorders

|September 13, 2024

概括

注意缺陷/多动障碍 (ADHD) 是大动脉中风 (LAS) 的危险因素. 根据这项遗传研究,内动脉瘤 (IA) 和未破裂的内动脉瘤 (UIA) 会增加精神分裂症的风险.

科学领域:

神经科学是一个神经科学.
遗传学遗传学是一个
流行病学流行病学

背景情况:

观察性研究表明精神障碍和脑血管疾病 (CVD) 之间的双向风险.
精神疾病和心血管疾病之间因果关系的遗传证据有限.
门德尔的随机化 (MR) 为调查因果关系提供了一种遗传方法.

研究的目的:

探索五种精神疾病和心血管疾病之间的遗传因果关系.
评估主要抑郁症,焦虑症,多动症,双相情感障碍或精神分裂症是否影响心血管疾病风险.
确定心血管疾病是否影响这些精神疾病的风险.

主要方法:

使用全基因组关联研究 (GWAS) 数据进行双样本,双向门德尔随机化 (MR) 分析.
仪器变量 (IV) 是与精神障碍和心血管疾病相关的单核酸多态 (SNP).
逆方差加权 (IVW) 方法是主要的;灵敏度分析包括MR-Egger,MR-PRESSO和异质性测试. 分析总结了研究结果.

主要成果:

前进MR:注意力缺陷/多动症 (ADHD) 显著增加任何中风 (AS),任何缺血性中风 (AIS) 和大动脉中风 (LAS) 的风险.
反向MR:内动脉瘤 (IA) 和未破裂的内动脉瘤 (UIA) 是精神分裂症的危险因素.
分析证实ADHD是LAS的风险因素,IA/UIA是精神分裂症的风险因素.

结论:

基因预测ADHD是大动脉中风 (LAS) 的危险因素.
内动脉瘤 (IA) 和未破裂的内动脉瘤 (UIA) 被确定为精神分裂症的危险因素.
这些发现对制定针对这些疾病的有针对性的预防策略有影响.

关键词:

有因果关系的因果关系.脑血管疾病脑血管疾病门德尔的随机化研究.精神障碍精神障碍精神障碍进行元分析分析.

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