化学辐射疗法后鼻腔状细胞癌患者治疗失败的模式
Li Wang1, Jie Wang1, Tian Wang1
1Department of Radiation Oncology, Eye, Ear, Nose & Throat Hospital of Fudan University, Shanghai 200031, China.
The British journal of radiology
|September 13, 2024
概括
局部复发和远程转移是用精确辐射治疗的鼻腔状细胞癌 (SNSCC) 患者的常见失败模式. 治疗因素和瘤特征预测这些失败.
科学领域:
- 辐射瘤学 辐射瘤学
- 头部和部癌症研究研究
- 医学物理学在瘤学中的应用
背景情况:
- 鼻腔状细胞癌 (SNSCC) 由于其复杂的解剖学,对放射治疗提出了独特的挑战.
- 了解失败模式对于改善SNSCC患者的治疗结果至关重要.
- 精确的辐射技术需要对治疗失败的详细分析.
研究的目的:
- 分析SNSCC患者接受精密辐射治疗的失败模式.
- 确定与局部复发和远程转移相关的预测因素.
- 评估治疗变量和瘤特征对生存结果的影响.
主要方法:
- 对441名连续SNSCC患者的214次治疗失败的回顾性分析.
- 经验丰富的放射瘤学家对瘤体积和复发模式的评估.
- 估计5年总生存期 (OS),无进展生存期 (PFS) 和无远程转移生存期 (DMFS).
- 后勤回归和生存分析,以确定治疗失败的预测因素.
主要成果:
- 观察到局部复发 (31.7%),区域性衰竭 (5.4%) 和远程转移 (14.7%).
- 在现场,边缘和现场外的故障分别占当地复发的55.7%,33.6%和10.7%.
- 治疗方式,化疗和手术边缘预测局部衰竭 (P < .01).
- 差差分化和R2切除边缘预测了远程故障 (P = .018,P = .009).
- 头骨底部参与和轨道入侵是较差的OS和PFS的独立预测因素.
结论:
- 局部复发和远程转移是SNSCC中占主导地位的故障模式.
- 治疗参数如模式,化疗和手术边缘显著影响局部复发.
- 瘤分化和切除边缘对于预测远程失败至关重要.
- 头骨底部和轨道干涉是生存的不利预后指标.
更多相关视频
07:29Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
Published on: April 22, 2019
11.5K
04:04Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
Published on: February 12, 2017
10.4K
相关概念视频
02:56Treatment Resistant Cancers
3.3K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.3K
02:49Cancer Therapies
7.6K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.6K