基因决定的非常高和非常低的LDL水平是否有助于Lp (a) 血度?
Antonina Giammanco1, Davide Noto1, Emilio Nardi1
1Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), Università degli Studi di Palermo, Via del Vespro 129, 90127, Palermo, Italy.
Nutrition, metabolism, and cardiovascular diseases : NMCD
|September 13, 2024
概括
患有家族性高胆固醇血症 (FH) 个体的脂质蛋白[Lp[a]水平高于1型家族性低血型蛋白质血症 (FHBL1) 或一般人群. 在FH患者中升高的Lp (a) 可能表明心血管疾病风险增加.
科学领域:
- 心血管医学 心血管医学
- 脂质学 脂质学是指脂质学.
- 遗传学 遗传学 是一个
背景情况:
- 脂蛋白 (Lp) 是动脉样硬化心血管疾病 (ASCVD) 的已知的危险因素.
- 关于不同心血管风险水平的Lp (a) 分布以及家族性高胆固醇血症 (FH) 和1型家族性低胆固醇蛋白质血症 (FHBL1) 等单基性失脂症的数据有限.
研究的目的:
- 为了研究血Lp (a) 水平的分布.
- 为了比较高和低LDL-C的受试者,特别是FH和FHBL1队列中的Lp (a) 水平,与普通人群进行比较.
主要方法:
- 研究包括356名高胆固醇患者 (212名具有FH突变,144名FH阴性),52名FHBL1受试者和797名自由生活的人.
- 分析比较了不同患者群体和心血管风险层中的Lp(a) 水平.
主要成果:
- 与FHBL1和一般人群 (中位数7.187.68 mg/dl) 相比,FH患者 (FH和FH阴性) 的Lp (a) 水平显著更高 (中位数12.4614.0 mg/dl).
- 在FH受试者中,Lp (a) 水平与LDLR缺陷与零突变和FH负的FH受试者相似.
- 患有高/非常高心血管风险的受试者比患有低/中等风险 (中位数5.727.80 mg/dl) 的受试者有显著更高的Lp(a) 水平 (中位数9.2010.68 mg/dl).
结论:
- 与FHBL1和一般人群相比,FH患者表现出较高的Lp(a) 水平.
- 在FH患者中,Lp (a) 可能导致高胆固醇血症.
- 结合Lp (a) 与FH其他风险因素的综合评估,可以识别高风险人群,为预防心血管事件提供早期,积极的治疗.
相关概念视频
Blood Studies for Cardiovascular System III: Serum Lipid Profile
135
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
135
Cholesterol: Significance and Regulation
519
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Considering cholesterol and...
519
Inflammation
53.2K
Overview
53.2K
Lipids: Dietary Sources and Requirements
708
Lipids are an essential component of a balanced human diet. Triglycerides, which make up the majority of dietary lipids, are found in both saturated fats—commonly present in meat, dairy products, and certain tropical plants like coconut, and hydrogenated oils such as margarine and baking shortenings (trans fats)—and unsaturated fats, which are abundant in seeds, nuts, olive oil, and most vegetable oils. The main sources of cholesterol include egg yolks, various meats and organ...
708
Lipid-derived Compounds in the Human Body
4.3K
Fats and lipids are crucial components in the human body. Some lipid-derived compounds, such as fat-soluble vitamins, eicosanoids, lipoproteins, and glycolipids, also play unique roles to support various biological processes .
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
4.3K
Overview of Lipid Metabolism
1.2K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
1.2K


