摄入和癌症风险之间的U形关联
Ngoan Tran Le1,2, Yen Thi-Hai Pham3,4, Chung Thi-Kim Le5
1Institute of Research and Development, Duy Tan University, Da Nang, Vietnam. letranngoan@duytan.edu.vn.
Scientific reports
|September 13, 2024
概括
这项研究发现越南的摄入量与癌症风险之间存在U形关联. 确定了降低癌症风险的最佳摄入量,低摄入量和高摄入量都会增加风险.
科学领域:
- 营养流行病学 营养流行病学
- 在瘤学瘤学.
- 生物化学 生物化学
背景情况:
- 对抗氧化酶和人类健康至关重要,但过量摄入可能是有害的.
- 对于亚洲人群来说,推的安全摄入量水平尚未确立.
- 了解在癌症预防中的作用至关重要,特别是在不同种族群体中.
研究的目的:
- 调查饮食摄入量与越南人口患各种癌症的风险之间的关联.
- 确定每日摄入的潜在安全范围,以减少癌症风险.
- 探索BMI,吸烟和饮酒等因素如何改变与癌症风险关系.
主要方法:
- 一项涉及越南3758例癌症病例和2929例对照病例的病例控制研究.
- 通过半定量性食物频率调查问卷来评估饮食摄入量.
- 使用无条件逻辑回归来计算赔率比率 (OR) 和95%置信区间 (CI).
主要成果:
- 在摄入量和整体癌症风险之间观察到显著的U形关联.
- 据估计,安全的每日摄入范围在110.8124.4μg/天 (平均117.8μg/天) 之间.
- 低摄入量 (27.877.2微克/天) 和高摄入量 (169.1331.7微克/天) 的都与癌症风险增加有关 (分别为OR=3.78和OR=1.86).
- 低BMI (<23 kg/m2) 和从未吸烟的人群中,U形关联更为明显.
- 这种模式在胃,结肠,直肠和肺癌中是一致的.
结论:
- 在越南人群中,饮食摄入量与癌症风险有U形的关联.
- 建议这个人群的平均摄入量为117.8μg/天作为安全水平.
- 需要进一步研究以阐明与癌症风险之间的U形关系背后的机制.
相关概念视频
Cancer Prevention
6.1K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.1K
Psychoneuroimmunology: Diabetes and Cancer
26
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
26
Cancer Survival Analysis
334
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
334
mTOR Signaling and Cancer Progression
3.8K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.8K
Mutagenicity and Carcinogenicity
1.2K
Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...
1.2K
Skin Cancer
4.0K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
4.0K


