在德鲁兹部落长寿中d3GHR载体表观基因组
Ghadeer Falah1, Alina Kurolap2, Tamar Paperna3
1Department of Human Biology, Faculty of Natural Sciences, University of Haifa, Haifa, Israel.
Scientific reports
|September 13, 2024
概括
该d3GHR基因变异与德鲁兹男性的寿命有关,显示出较年轻的生物年龄. 这突显了遗传学,环境和表观遗传学在健康结果中的相互作用.
科学领域:
- 遗传学和表观遗传学
- 人类寿命研究 长寿研究
- 人口遗传学 人口遗传学
背景情况:
- 德鲁兹人口由于历史血缘关系而表现出独特的遗传特征.
- 德鲁兹部落中的异常长寿个体 (ELLI) 提供了一个研究长寿因素的机会.
- 研究生们正在研究生长激素受体 (GHR) 基因及其多态基因在衰老中的作用.
研究的目的:
- 为了研究d3GHR多态性和德鲁兹男性的长寿之间的联系.
- 探索表观遗传修饰的作用,特别是DNA甲基化,在介导GHR基因型对衰老的影响.
- 为了确定d3GHR变异是否赋予生物年龄优势.
主要方法:
- 73名德鲁兹氏族成员的基因定型,用于d3GHR多态.
- 对14个具有不同GHR基因型的家族成员的DNA甲基化模式的分析.
- 使用生物年龄钟来评估基因型对衰老速度的影响.
主要成果:
- 在8.2%的部落成员中发现了d3GHR异型,近11%的男性携带它.
- 在男性中观察到与年龄相关的d3GHR异型显著增加 (p=0.04).
- 发现DNA甲基化水平与年龄之间存在负相关性 (p<0.05),而d3GHR组的生物年龄优势为+4.229岁.
结论:
- 在研究的德鲁兹人群中,d3GHR多态性与长寿优势有关.
- 表观遗传调节,特别是DNA甲基化,在调解影响健康和衰老的基因型环境相互作用方面发挥着作用.
- 这项研究强调了遗传和环境因素对人类寿命的重要性.
更多相关视频
07:25Lipid Supplementation for Longevity and Gene Transcriptional Analysis in Caenorhabditis elegans
Published on: December 9, 2022
1.5K
09:23Quantification of Information Encoded by Gene Expression Levels During Lifespan Modulation Under Broad-range Dietary Restriction in C. elegans
Published on: August 16, 2017
8.0K
相关概念视频
Exon Recombination
3.6K
The evolution of new genes is critical for speciation. Exon recombination, also known as exon shuffling or domain shuffling, is an important means of new gene formation. It is observed across vertebrates, invertebrates, and in some plants such as potatoes and sunflowers. During exon recombination, exons from the same or different genes recombine and produce new exon-intron combinations, which might evolve into new genes.
Exon shuffling follows “splice frame rules.” Each exon...
Exon shuffling follows “splice frame rules.” Each exon...
3.6K
Inheritance of Chromatin Structures
6.2K
Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying...
6.2K
Epigenetic Regulation
3.0K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
X-chromosome...
3.0K
Replication in Eukaryotes
13.6K
In eukaryotic cells, DNA replication is highly conserved and tightly regulated. Multiple linear chromosomes must be duplicated with high fidelity before cell division, so there are many proteins that fulfill specialized roles in the replication process. Replication occurs in three phases: initiation, elongation, and termination, and ends with two complete sets of chromosomes in the nucleus.
Many Proteins Orchestrate Replication at the Origin
Eukaryotic replication follows many of the same...
Many Proteins Orchestrate Replication at the Origin
Eukaryotic replication follows many of the same...
13.6K
Position-effect Variegation
6.3K
In 1928, a German botanist Emil Heitz observed the moss nuclei with a DNA binding dye. He observed that while some chromatin regions decondense and spread out in the interphase nucleus, others do not. He termed them euchromatin and heterochromatin, respectively. He proposed that the heterochromatin regions reflect a functionally inactive state of the genome. It was later confirmed that heterochromatin is transcriptionally repressed, and euchromatin is transcriptionally active chromatin.
6.3K
Genomic Imprinting and Inheritance
34.2K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
34.2K
