气对脂肪组织中氧化应激反应的影响
Batkhishig Tumurbaatar1, Shinji Ogawa1,2, Nobuhisa Nakamura3,4
1Department of Cardiovascular Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, 467- 8601, Japan.
Scientific reports
|September 13, 2024
概括
气可能为脂肪组织的氧化应激提供治疗效益. 这项研究发现减少了脂肪细胞大小和改变了皮的表达,这表明它有可能治疗相关疾病.
科学领域:
- 生物医学科学 生物医学科学
- 代谢研究研究 代谢研究
- 氧化压力生物学 氧化压力生物学
背景情况:
- 脂肪组织中的氧化应激会扰乱脂肪基因分泌,可能导致动脉样硬化.
- 对经历氧化应激的脂肪组织的治疗效果尚不清楚.
研究的目的:
- 研究气对人类皮下脂肪组织中氧化应激的治疗潜力.
- 评估气对脂肪细胞大小和关键氧化应激标志物和adipokines的表达的影响.
主要方法:
- 人体皮下脂肪组织 (SCAT) 样本从接受开放心脏手术的患者中收集.
- 脂肪组织爆炸物被处理在体外生成的溶介质.
- 对氧化应激标志物 (Nrf2,HO-1,SOD) 进行了免疫抑制,并分析了脂肪细胞大小.
- 评估了阿迪波内克丁和化学素的基因表达.
主要成果:
- 治疗导致核因素红色素2相关因子2 (Nrf2) 和血红氧酶-1 (HO-1) 表达的显著下降.
- 观察到一种趋势,即超氧化物脱酶 (SOD) 表达的增加.
- 化导致脂肪细胞大小的减少.
- 基因表达分析表明,阿迪波内克丁的增加和化学素水平的降低趋势.
结论:
- 气证明了减轻脂肪组织中氧化应激的治疗潜力.
- 治疗可能会减少脂肪细胞的大小,并有利地调节类蛋白质的配置,这表明对代谢健康有影响.
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