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Updated: Jun 13, 2025

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多焦点,多现象型瘤是由早期胚胎发生过程中获得的MTOR突变引起的

Clarissa N Pacyna1, Madhanagopal Anandapadamanaban2, Kevin W Loudon3,4

  • 1Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.

Oncogene
|September 13, 2024
PubMed
概括

早期胚胎突变可能导致儿科瘤. 在四种同步瘤中,一个共享的MTOR突变源自单个胚胎细胞,影响mTORC1/mTORC2活动并指导治疗决策.

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