肠道微生物多样性与危及视力的糖尿病视网膜病变的相关性
Rehana Khan1,2, Abhishek Sharma3, Raghul Ravikumar4
1Shri Bhagwan Mahavir Vitreoretinal Services, Sankara Nethralaya, Sankara Nethralaya, 18 College Road, Chennai, 600 006, Tamil Nadu, India.
BMC microbiology
|September 13, 2024
概括
肠道微生物群的多样性与危及视力的糖尿病视网膜病变 (STDR) 有关. 虽然整体多样性没有显示出差异,但在STDR患者中,较高的细菌体/细菌体比率与微生物丰富性和均性降低相关,特别是在多发性糖尿病视网膜病变中.
科学领域:
- 微生物学 微生物学
- 眼科医生 眼科 眼科
- 胃肠病学 胃肠病学
背景情况:
- 糖尿病视网膜病变 (DR) 是糖尿病患者视力丧失的主要原因.
- 肠道微生物组在包括糖尿病并发症在内的全身性疾病中的作用是一个新兴的研究领域.
- 了解肠道微生物组的变化可能会为DR病原发生提供新的见解.
研究的目的:
- 研究糖尿病患者的肠道微生物群多样性与视力威胁性糖尿病视网膜病变 (STDR) 之间的关联.
- 探索细菌菌体/菌体 (B/F) 比率与性传播疾病发病率之间的关系.
主要方法:
- 这是一项涉及54名参与者的横截面研究,分为STDR病例和对照组.
- 病例和对照之间的肠道微生物α多样性的比较.
- 对B/F比率 (切断值1.05) 的分析,以确定与STDR和特定DR亚型的关联.
主要成果:
- 在STDR病例和对照之间,整体肠道微生物α多样性没有统计学上显著的差异.
- 基于多个多样性指数 (ACE,Chao1,Simpson,Shannon) 的B/F比 (≥1.05对<1.05) 观察到微生物多样性的显著差异.
- 亚组分析显示,STDR患者的多样性减少,B/F比率≥1.05,增殖性糖尿病视网膜病变 (PDR) 的物种丰富性和均性显著减少,临床显著的斑点 (CSME) 的物种丰富性显著减少.
结论:
- 在STDR患者中观察到肠道微生物多样性的减少,特别是与B/F比率相关.
- B/F比似乎是一个比整体多样性更敏感的肠道微生物组改变STDR的指标.
- 研究结果表明,肠道微生物组失调,以减少物种丰富性和均性为特征,可能有助于STDR的发病,特别是在PDR和CSME中.
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