奥拉巴里布诱导的间歇性肺病的临床和放射学模式
Alexandre Brudon1, Dorine Fournier2, Frédéric Selle3
1Thoracic Oncology Department, Université Paris Cité, CIC INSERM 1425, Institut du Cancer AP-HP.Nord, Hôpital Bichat-Claude Bernard, 46 Rue Henri Huchard, Paris, 75108, France. alexandre.brudon01@chu-lyon.fr.
肺炎是PARP抑制剂 (PARPi) 的罕见副作用,特别是olaparib. 早期停止和治疗可以导致康复,并有可能安全地与其他PARPi重新挑战.
科学领域:
- 在瘤学瘤学.
- 肺部病理学 肺部病理学
- 药物监督 药物监督 药物监督
背景情况:
- 多 (ADP-ribose) 聚合酶抑制剂 (PARPi) 治疗各种癌症,但肺炎是已知的不良事件.
- 与其他PARPi相比,Olaparib显示肺炎的风险更高.
- 在高加索人群中,Olaparib诱导的间歇性肺病 (O-ILD) 数据有限.
研究的目的:
- 在高加索患者中调查Olaparib诱导的间歇性肺病 (O-ILD).
- 描述O-ILD的临床表现,诊断和结果.
主要方法:
- 使用法国和比利时药监数据 (2018-2022) 的回顾性研究.
- 药理学家和肺病学家/放射学家对O-ILD病例的中央审查.
- 分析包括因果关系评估和诊断标准的遵守.
主要成果:
- 确定了五名患有O-ILD的白人患者;所有这些患者都是患有卵巢或乳腺癌的女性.
- 平均年龄71岁,非吸烟者;症状出现在olaparib开始后12周.
- 肺炎严重 (3/2级),CT扫描显示为过敏性肺炎.
- 支气管膜洗显示有淋巴细胞膜炎;治疗包括停止olaparib和葡萄糖皮质类药物.
- 在研究队列中没有致命病例;两名患者安全地重新接受了PARPi.
- 在世卫组织VigiBase中发现了40个额外的O-ILD病例,其中包括一个致命病例.
结论:
- 与PARPi相关的间歇性肺病 (PARPi-ILD) 是罕见的,但可能致命的.
- 过敏性肺炎是一种常见的模式,发生在PARPi启动后3个月内.
- 停止违规PARPi是主要的治疗方法;可能会考虑重新挑战.
更多相关视频
08:05Lung CT Segmentation to Identify Consolidations and Ground Glass Areas for Quantitative Assesment of SARS-CoV Pneumonia
Published on: December 19, 2020
07:54Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice
Published on: December 21, 2019
相关概念视频
01:13Radiological Investigation III: Pulmonary Angiogram and PET Scan
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
01:30Radiological Investigation II: MRI and Ventilation Perfusion Scan
Magnetic Resonance Imaging (MRI) and Ventilation Perfusion Scans are two radiological investigations that offer detailed diagnostic images of the body, particularly lung structures.
MRI
MRI uses magnetic fields and radiofrequency signals to distinguish between normal and abnormal tissues. This technology provides a more detailed diagnostic image than CT scans, enabling it to characterize pulmonary nodules, stage bronchogenic carcinoma, and evaluate inflammatory activity in...