睡眠模式,体力活动,遗传易感性和发生的类风湿性关节炎:一个前性队列研究
Jing Ni1,2,3, Qiang Zhou4,5, Shi-Ying Meng6,7,4
1Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China. nijing@ahmu.edu.cn.
BMC medicine
|September 13, 2024
概括
采用健康的睡眠模式和适度的体力活动 (PA) 可以显著降低类风湿性关节炎 (RA) 风险. 这些生活方式选择甚至可以抵消对RA的遗传倾向,强调它们在预防中的重要性.
科学领域:
- 类风湿病学 类风湿病学
- 流行病学 流行病学
- 睡眠科学 睡眠科学
背景情况:
- 类风湿性关节炎 (RA) 的发展与睡眠和体力活动 (PA) 有关,但确切的关系需要量化.
- 研究睡眠,PA和RA发病率的遗传易感性之间的相互作用对于了解疾病病因至关重要.
研究的目的:
- 量化睡眠行为,PA和遗传敏感性对类风湿性关节炎 (RA) 发病率的纵向影响.
- 估计睡眠模式,PA和RA遗传风险因素之间的综合影响和相互作用.
主要方法:
- 使用考克斯的比例危险模型,对一个大型欧洲队列 (n=363,211) 的分析.
- 根据五种行为 (持续时间,失眠,打,时间型,白天嗜睡) 和健康睡眠得分来定义睡眠模式.
- 评估了睡眠,PA和遗传敏感性与RA风险的个人和组合关联,包括相互作用分析 (P相互作用,RERI).
主要成果:
- 健康的睡眠模式与降低了RA风险 (HR 0.79;95% CI 0.75-0.84),独立于遗传学.
- 观察到PA和RA风险之间的非线性关联,中间PA水平显示最低风险 (HR 0.84;95% CI 0.76-0.92).
- 健康睡眠和中度PA之间的添加性相互作用表明,RA风险显著降低 (RERI 0.45;95% CI 0.02-0.87),对遗传敏感个体尤其有益.
结论:
- 健康的睡眠模式和适度的体力活动 (PA) 与患类风湿性关节炎 (RA) 的风险降低有关.
- 这些可修改的生活方式因素可以减轻对RA的遗传倾向的影响.
- 将健康的睡眠和PA纳入公共卫生战略可以帮助预防RA.
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