空气污染和抑郁症遗传风险对静止状态功能连接的处理速度的交互作用
Yuyanan Zhang1, Zhe Lu2, Yaoyao Sun1
1Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, 100191, China.
BMC medicine
|September 13, 2024
概括
暴露于空气污染,特别是细颗粒物 (PM2.5),可能会在患有重大抑郁症 (MDD) 的遗传风险较高的人中恶化认知功能. 这种相互作用会影响静止状态的大脑连接,特别是在默认模式网络中.
科学领域:
- 神经科学是一个神经科学.
- 环境健康 环境健康
- 精神病学是一个精神病学.
背景情况:
- 空气污染与严重抑郁症 (MDD) 中出现的认知障碍有关.
- 关于空气污染和遗传性抑郁风险对认知的综合影响的研究有限.
- 这项研究调查了空气污染,遗传风险和MDD的认知功能之间的相互作用.
研究的目的:
- 检查空气污染和遗传倾向如何相互作用以影响MDD的认知功能.
- 使用fMRI调查这种相互作用对静止状态大脑功能的影响.
- 确定受空气污染和遗传风险影响的特定大脑区域和网络.
主要方法:
- 在北京对497名健康成年人进行了横截面研究,这些成年人对细颗粒物 (PM2.5) 的暴露程度各不相同.
- 根据住宅地址评估了6个月的环境PM2.5暴露.
- 使用功能性磁共振成像 (fMRI),认知评估和多基因风险评分 (PRS) 进行MDD.
主要成果:
- 在具有高MDD遗传风险 (PRS) 的个体中,PM2.5暴露降低了先性连接性.
- 这种相互作用影响了前额外外和前额外边缘默认模式网络区域的全球功能连接.
- 增加的PM2.5暴露与左角和cuneus gyri的连接性改变相关,对处理速度产生负面影响.
结论:
- 空气污染可能会增加遗传倾向的个体的认知障碍风险.
- 脑后垂体和默认模式网络静止状态功能的改变是潜在的机制.
- 研究结果强调了环境和遗传因素对大脑功能和认知的综合影响.
相关概念视频
Human Genetics
547
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
547
Depressive Disorders: Etiology
58
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
58
Background and Environment Affect Phenotype
6.5K
Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as temperature, oxygen availability, presence of mutagens, that can alter an organism’s phenotype.
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
6.5K
Depression: Overview
227
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
227
Stress and Mental Health
86
Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...
Individuals with depression often experience challenges in both their personal and professional...
86


