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Updated: Jun 13, 2025

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

Published on: October 26, 2015

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作为CDK2抑制剂和抗癌剂的氧化-西醇混合物:设计,合成和生物评估

Heba T Abdel-Mohsen1

  • 1Chemistry of Natural and Microbial Products Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre, Dokki, P.O. 12622, Cairo, Egypt. ht.abdel-mohsen@nrc.sci.eg.

BMC chemistry
|September 13, 2024
PubMed
概括

合成了新的氧醇-西醇混合物,以准CDK2用于癌症治疗. 化合物9o显示出显著的抗癌活性,阻止细胞循环和诱导细胞亡,具有有利的ADME特性用于进一步开发.

关键词:
它具有抗癌活性.它具有CDK2抑制活性.设计设计设计设计设计设计.分子对接是分子对接.氧醇佐亚醇的使用方法综合合成 综合合成

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