相关实验视频
Updated: Jun 13, 2025

06:32
Isolation of Preadipocytes from Broiler Chick Embryos
Published on: August 4, 2022
2.2K
黑斯佩里丁有助于改善肠道结构,维持屏障功能,并减少暴露于高温的黄色羽毛肉的炎症
Shaoping He1,2, Guozhi Bian2, Yuming Guo1
1College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
Animals : an open access journal from MDPI
|September 14, 2024
概括
在 brojiler饮食中补充hesperidin可以通过减少炎症标志物和改善肠道屏障功能来保护热应激诱导的肠道损伤. 这项研究强调了hesperidin.
科学领域:
- 动物科学动物科学
- 营养生物化学 营养生物化学
- 禽畜科学 禽畜科学 禽畜科学
背景情况:
- 高温热应激对肉健康和肠道完整性产生负面影响.
- 类植物中的一种类黄素hesperidin因其潜在的抗炎和保护性质而受到研究.
研究的目的:
- 评估饮食中的hesperidin在缓解黄色羽毛肉的热应激诱导肠道损伤方面的疗效.
- 调查hesperidin对生理压力标志物,肠道形态,屏障功能和炎症反应的影响.
主要方法:
- 960只21天大的黄羽肉被 subjected to heat stress,并补充了不同水平的hesperidin (0,300,450,600毫克/公斤).
- 测量了皮质,上腺皮质激素,内毒素,D-乳酸,IL-1β,IL-6和TNF-α的血清水平.
- 分析了肠道形态 (密室深度,V/C比率) 和紧结蛋白 (claudin-1,ZO-1) 和NF-κB的基因表达.
主要成果:
- 黑斯匹里丁补充剂降低了血清皮质和上腺皮质激素水平.
- 补充300和450毫克/公斤的hesperidin改善了小肠道形态,并增加了claudin-1和ZO-1mRNA的表达.
- 赫斯佩里丁降低了内毒素,D-乳酸,IL-1β,IL-6,TNF-α和NF-κBmRNA水平,表明炎症减少和改善了肠道屏障完整性.
结论:
- 饮食中的hesperidin证明了对黄色羽毛肉的热应激诱导的肠损伤的保护作用.
- 素减轻了压力激素的升高,增强了肠道屏障功能,并减少了全身炎症,这表明它在热应激条件下作为家禽料添加剂的潜力.
相关概念视频
Role Of Notch Signalling In Intestinal Stem Cell Renewal
2.1K
Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
2.1K
Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal
2.2K
Erythropoietin-producing hepatocellular carcinoma receptor (Eph) and its ligand, Eph receptor-interacting protein (Ephrin) were first discovered in the human carcinoma cell line, hence the name. Ephrin-Eph interaction guides cells to reach their appropriate location in adult tissues. They also play an essential role in the immune system by helping in immune cell migration, adhesion, and activation. Based on their structure and function, Eph is divided into two classes — EphA and EphB.
2.2K

