由Lactobacillus plantarum发酵的Lonicera japonica改善多种模式驱动的骨质疏松症
Zimin Chen1, Weiye Xu1, Jianming Luo1
1Department of Food Science and Engineering, Jinan University, Guangzhou 510632, China.
Foods (Basel, Switzerland)
|September 14, 2024
概括
发酵蜜溶液 (FS) 通过改善骨密度和减少炎症,有望对抗骨质疏松症. 这种功能性食物可能有助于恢复肠道细菌和血液代谢物,为骨健康提供一种自然的方法.
科学领域:
- * 药理学和营养药品
- * 骨生物学与疾病
- * 微生物组研究
背景情况:
- *骨质疏松症 (OP) 是一个重要的全球健康问题,需要新的治疗策略.
- *功能性食品,包括发酵的花 (Lonicera japonica) 溶液 (FS),由于其抗炎和增强免疫力的特性,有可能减轻OP.
- *发酵显著改变了花的成分,丰富了其代谢物概况.
研究的目的:
- * 为了研究发酵花粉溶液 (FS) 在甲诱导的骨质疏松症的小鼠模型中的疗效.
- * 探索FS对骨矿物质密度 (BMD),骨微型结构和关键骨代谢标记物的影响.
- * 在OP的背景下阐明FS在调节肠道微生物组和血清代谢组中的作用.
主要方法:
- * 在使用德甲的老鼠中诱导了骨质疏松症.
- *鼠被用发酵的花粉溶液 (FS) 治疗.
- * 评估了骨矿物质密度 (BMD),骨微型结构,血清,骨素 (OCN),酸耐酸酸酶-5b (TRACP-5b) 和促炎细胞因子 (TNF-α,IL-6). 用斯皮尔曼相关性分析了肠道细菌属和血清代谢物.
主要成果:
- *在OP大鼠中,FS治疗显著增强了骨质量,改善了骨微观结构,并增加了血清水平.
- *FS的使用导致TRACP-5b,TNF-α和IL-6的水平降低,同时增加了OCN水平.
- *FS干预恢复了6种特定细菌属的丰富性和17种血清代谢物的水平,与OP缓解相关.
结论:
- * 发酵花溶液 (FS),特别是以Lactobacillus plantarum发酵的花,有效地减轻了老鼠模型中的骨质疏松症.
- *FS通过调节肠道微生物组和血清代谢组,促进骨质细胞分化和减少炎症来发挥其治疗作用.
- *这项研究为开发FS作为治疗骨质疏松症的功能性食物提供了科学基础.
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