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在淋巴结转移性乳头甲状腺癌中PD-L1和NIS表达之间没有相关性

Lévay Bernadett¹, Kiss Alexandra¹, Fröhlich Georgina²

¹National Institute of Oncology, Multidisciplinary Head and Neck Cancer Center, 1124 Budapest, Hungary.

Diagnostics (Basel, Switzerland)

|September 14, 2024

概括

这项研究没有发现/合载体 (NIS) 与皮肤状甲状腺癌中编程死亡配体1 (PD-L1) 表达之间的相关性. 了解这些标志物对于开发用于抗放射性分化甲状腺癌的新疗法至关重要.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
免疫学免疫学免疫学

背景情况:

分化甲状腺癌 (DTC),主要是乳头甲状腺癌 (PTC),是常见的内分泌恶性瘤.
放射性 (RAI) 剥离是一种标准治疗方法,但放射性耐火DTC构成了治疗挑战.
甲状腺癌的脱差可以导致放射性吸收的丧失,原因是/合载体 (NIS) 表达的受损,并观察到编程死亡连接体1 (PD-L1) 的增加.

研究的目的:

在淋巴结转移性PTC的原发性瘤样本中,研究人类/同载体 (hNIS) 和编程死亡联体1 (PD-L1) 表达之间的相关性.
分析NIS和PD-L1在PTC中的共同表达模式,以了解它们在放射性折射性中的潜在作用.

主要方法:

免疫组织化学用于分析hNIS和PD-L1在转移性PTC患者的原发性瘤样本中的表达.
根据阳性细胞的百分比评估PD-L1表达,并通过任何亚细胞局部 (细胞质或膜质) 评估NIS表达.
分析了89个PD-L1的PTC病例和86个NIS病例的数据.

主要成果:

在86个 (59.3%) 的PTC瘤中,在51个瘤中观察到NIS的表达,大多数瘤显示出细胞内的局部化而不是血表达.
在89个PTC瘤中的64个 (71.9%) 中检测到PD-L1表达,阳性细胞的百分比不同.
在分析的PTC样本中,PD-L1表达水平和NIS表达之间没有发现统计学意义上的相关性.

结论:

在淋巴结转移PTC的初级瘤中没有观察到PD-L1和NIS表达之间的相关性.
虽然PD-L1/PD-1轴操纵是一种潜在的治疗策略,但这项研究不支持它与恢复PTC中NIS功能的直接联系,基于协同表达分析.
需要进一步的研究来探索放射性耐火DTC的间接机制或替代治疗点.

关键词:

在NIS表达式中,使用NIS表达式.在 PD-L1 表达式上.甲状腺乳头癌是甲状腺乳头癌.

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