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生殖尿道癌患者的免疫相关不良事件,一项回顾性队列研究
John C Hunting1, Logan Deyo1, Eric Olson2
1Department of Internal Medicine, Wake Forest School of Medicine, Wake Forest University, Winston-Salem, NC 27157, USA.
Cancers
|September 14, 2024
概括
免疫检查点抑制剂 (ICI) 广泛用于生殖尿道癌症. 与其他瘤相比,细胞癌 (RCC) 患者面临与免疫相关的不良事件 (irAEs) 的风险更高,尽管生存益处仍然相似.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 癌症研究 癌症研究
背景情况:
- 免疫检查点抑制剂 (ICI) 是生殖尿道癌症 (GUc) 的标准治疗方法.
- 了解与ICI相关的免疫相关不良事件 (irAEs) 非常重要,因为它们的使用越来越多.
- 风险因素,比较概况和irAEs的时间要求进行彻底的调查.
研究的目的:
- 分析用ICI治疗的泌尿生殖系统癌症患者中irAEs的发病率和概况.
- 为了比较接受ICI的细胞癌 (RCC) 和尿路细胞癌 (UC) 患者之间的irAEs.
- 评估iRAE对GUc患者生存结果的影响.
主要方法:
- 3101名患者的回顾性注册,接受至少一剂ICI治疗.
- 获得了IRB对数据收集和分析的批准.
- 对于二分结果的多变量逻辑回归和生存分析的多变量考克斯回归.
主要成果:
- 196名患者患有RCC,170名患者患有泌尿器瘤.
- 风险性癌症患者出现irrAEs的可能性更高 (OR 1.78;95% CI 1.32-2.39).
- 脊髓癌患者更容易患上皮肤炎,甲状腺炎,急性损伤和心肌炎;泌尿腺癌患者在irAE概况中没有显著差异.
结论:
- 与大多数其他瘤相比,细胞癌 (RCC) 呈现出明显的免疫相关不良事件 (irAE) 概况.
- 在接受ICI治疗时,RCC患者更容易发生任何irrAEs.
- 基于尿生殖系统癌症的irAEs,没有观察到生存益处的显著异质性.
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