血动力学力量:在多发性骨髓瘤心血管基线风险评估中室重塑的新兴标志物
Anna Colomba1,2, Anna Astarita2, Giulia Mingrone1,2
1Candiolo Cancer Institute, FPO—IRCCS, 10060 Candiolo, TO, Italy.
Cancers
|September 14, 2024
概括
多发性骨髓瘤患者表现出改变的血液动力学力 (HDFs),无论高血压,表明潜在的早期心肌损伤. 在这些患者中,HDF分析可能有助于控制心血管风险.
科学领域:
- 心脏病学 心脏病学
- 在瘤学瘤学.
- 生物医学工程 生物医学工程
背景情况:
- 多发性骨髓瘤 (MM) 患者患心血管疾病的患病率很高.
- 准确的心血管风险评估对于安全的MM治疗方案至关重要.
- 血液动力学力 (HDFs) 分析比标准标记物更早地检测到心肌损伤.
研究的目的:
- 为了研究多发性骨髓瘤 (MM) 患者的血液动力学力 (HDF) 改变.
- 为了比较MM患者的HDF,高血压和没有高血压对照.
- 评估MM和高血压对心血管参数的影响.
主要方法:
- 胸外回声心电图用于HDF分析和脉冲波速度 (PWV) 评估.
- 173名患者被分为MM高血压 (MMHT),MM高血压 (MMNT),控制高血压 (CoHT) 和控制高血压 (CoNT).
主要成果:
- 与CoNT相比,高血压患者 (MMHT,CoHT) 呈现出减少的喷射分数 (EF),全球纵向应变 (GLS) 和HDF,心室质量 (LVMi) 和PWV增加.
- 在MMNT患者中,缩和缩射出的HDFs与CoNT相比显著减少,EF,GLS,LVMi或PWV没有变化.
结论:
- 多发性骨髓瘤诱导心室重塑,无论高血压状态.
- 对MM患者的HDF分析可以促进心肌损伤的早期检测,特别是那些服用心脏毒性药物的人.
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