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皮肤状细胞癌在患有固体器官移植相关免疫抑制的患者中

Karam Khaddour^1,2,3, Naoka Murakami^3,4, Emily S Ruiz^2,3,5

¹Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.

|September 14, 2024

概括

免疫疗法已推进皮肤状细胞癌 (CSCC) 治疗. 本综述探讨了固体器官移植接受者 (SOTRs) 中的CSCC管理,重点关注免疫抑制.

科学领域:

瘤学和免疫学
移植医学移植医学

背景情况:

通过免疫疗法转变的高级皮肤状细胞癌 (CSCC) 管理.
免疫疗法的有效性取决于强大的抗瘤免疫反应.
固体器官移植接受者 (SOTRs) 的CSCC发病率增加.

研究的目的:

审查免疫抑制SOTRs中CSCC的流行病学,病理生理学和管理.
分析免疫抑制对CSCC的预后影响.
检查SOT患者中CSCC发展风险.

主要方法:

对免疫抑制群体中CSCC的综合文献综述.
在移植的CSCC患者中分析生物免疫干扰.
评估当前免疫疗法证据和管理框架.

主要成果:

免疫抑制显著影响CSCC的预后.
移植患者因免疫抑制疗法而面临CSCC风险升高.
在免疫抑制的CSCC患者中发现了特定的免疫干扰.

结论:

建议与CSCC一起管理SOTR的框架.
对免疫抑制的CSCC患者的新型治疗方法的讨论.
突出了对这一群体量身定制的管理策略的需要.

关键词:

皮肤状细胞癌瘤免疫性受损的人.免疫抑制是一种免疫抑制.免疫疗法免疫疗法一个固体器官移植器官.

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