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通过瘤微环境响应向SWCNT交付实现的协同光热疗法和化疗

Shuoye Yang^1,2, Jiaxin Liu¹, Huajian Yuan¹

¹School of Biological Engineering, Henan University of Technology, Zhengzhou 450001, China.

International journal of molecular sciences

|September 14, 2024

概括

这项研究开发了结合光热疗法 (PTT) 和化疗的新型纳米输送系统,以加强癌症治疗. 该系统表现出显著的瘤抑制和良好的安全性,对未来的癌症治疗有希望.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
在瘤学瘤学.

背景情况:

光热疗法 (PTT) 结合化疗提供了协同作用的抗瘤效应.
开发先进的纳米输送系统对于有针对性的癌症治疗至关重要.

研究的目的:

创建一个新的纳米输送系统 (HD/CNTs-SS-ICG@DOX) 用于协同化疗和PTT.
评估开发的纳米输送系统的 in vitro 和 in vivo 抗瘤疗效和安全性.

主要方法:

合成的二硫化物键敏感纳米载体使用氨酸绿色氨基 (ICG-NH2) 和酸性单壁碳纳米管 (CNTs).
功能化的CNT与氨酸 (HA) 和DMPE用于有针对性的输送.
在纳米载体上加载多克索鲁比辛化物 (DOX),以创建HD/CNTs-SS-ICG@DOX.
在试验室中评估了细胞毒性,细胞亡,细胞循环分布和反应性氧物种 (ROS) 生产.
在携带瘤的小鼠体内评估的抗瘤活性和生物组织安全性.

主要成果:

在实验室中,HD/CNTs-SS-ICG@DOX系统有效诱导了MCF-7癌细胞死亡.
在体内观察到显著的瘤生长抑制,这是由于化疗和PTT的协同作用.
开发的纳米输送系统表现出良好的生物组织安全性.

结论:

复合CNT输送系统显示出高生物相容性,有针对性的输送和响应性药物释放.
实现了化疗和PTT的有效协调,突出了癌症治疗中的广泛应用前景.
这种纳米输送系统代表了用于协同癌症治疗的有希望的战略.

关键词:

这就是SWCNTs.光热疗法是一种光热疗法.协同疗法是一种协同疗法.有针对性的交付目标.瘤微环境的反应反应

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