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基于纳米纤维的眼科插件的配方和开发,用于治疗细菌结膜炎
Eszter Farkas1, Houssam Abboud1, Nándor Nagy2
1Center of Pharmacology and Drug Research & Development, University Pharmacy Department of Pharmacy Administration, Semmelweis University, Hőgyes Endre Street 7-9, H-1092 Budapest, Hungary.
International journal of molecular sciences
|September 14, 2024
概括
这项研究开发了新的,无防腐剂的levofloxacin纳米纤维用于治疗眼睛感染. 这些插件提供快速的药物释放,良好的生物相容性和增强的抗菌疗效,改善患者的坚持.
科学领域:
- 眼科医生 眼科 眼科
- 材料科学 材料科学 材料科学
- 药品制造 药品制造 药品制造
背景情况:
- 眼科感染需要有效的药物输送系统.
- 传统的眼滴可能会引起刺激,需要经常服用.
- 没有防腐剂的配方是理想的,以尽量减少眼睛表面的毒性.
研究的目的:
- 开发和描述新型的,含有levofloxacin的,无防腐剂的纳米纤维基插件,用于眼科输送.
- 评估开发系统的药物释放,生物相容性和抗菌疗效.
- 评估该系统作为常规眼滴的替代品的潜力.
主要方法:
- 聚乙烯醇 (PVA) 和Poloxamer 407 (Polox) 的电与勒沃素和基基β-环氧化 (HP-β-CD).
- 使用扫描电子显微镜 (SEM),富里埃变换红外光谱 (FTIR) 和X射线衍射 (XRD) 进行表征.
- 在体外溶解,细胞毒性测定 (用氨酸),以及对眼睛病原体的抗菌活性测试.
主要成果:
- 统一的纳米纤维形态被SEM证实.
- 在纤维 (FTIR,XRD) 中发现了无形状态的利沃素.
- 观察到快速 (在2分钟内) 和完整的药物释放;更高的HP-β-CD稍微延迟释放.
- 含有氨酸的配方显示改善了生物相容性.
- 纳米纤维表现出与MICs较低的常规眼滴相比具有可比或优越的抗菌疗效.
- 一种特定的配方 (PVA-Polox,药物:CD 1:1,0.4%氨酸盐) 显示出极好的性能.
结论:
- 含有levofloxacin,无防腐剂的纳米纤维为眼科感染提供了一个有希望的替代方案.
- 该系统表现出快速溶解,良好的生物相容性和增强的抗菌活性.
- 凝性质和改善的保留时间可能会增加患者的遵从性和治疗结果.
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