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发现阿洛佩林作为一种潜在的抗瘤剂,用于携带突变IDH1突变的胆管癌

Xingkang Wu1, Yang Li1, Chenchen Han1

  • 1Modern Research Center for Traditional Chinese Medicine, Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Shanxi University, No. 92, Wucheng Road, Taiyuan 030006, China.

International journal of molecular sciences
|September 14, 2024
PubMed
概括

素化物之一的阿洛佩林 (Aloperine) 通过向IDH突变细胞,对肝脏内胆管癌 (ICC) 产生强大的抗癌作用. 这种化合物可能为ICC治疗提供新的治疗策略.

关键词:
这是一种D-2-基酸盐.发生IDH突变的IDH突变.阿洛佩林 (aloperine) 是一种可以在肝脏内发生的胆固醇癌 (cholangiocarcinoma).奇诺利齐丁类类化合物

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