干扰B细胞的补充受体表达模式被扩大了在扩散性皮肤系统性硬化症中类似收受体CD180结合的收费方式
Szabina Erdő-Bonyár1, Judit Rapp1, Rovéna Subicz1
1Department of Immunology and Biotechnology, Clinical Center, University of Pécs Medical School, H-7624 Pécs, Hungary.
International journal of molecular sciences
|September 14, 2024
概括
系统性硬化症 (SSc) 涉及B细胞功能障碍. 像补充受体 (CRs) 和托尔类受体 (TLRs) 这样的先天性免疫分子会影响SSc中的B细胞,可能促进自身抗体的产生.
科学领域:
- 免疫学 免疫学 免疫学
- 类风湿病学 类风湿病学
- 自免疫性疾病 自免疫性疾病
背景情况:
- B细胞的自身抗体产生是系统性硬化症 (SSc) 病原体的核心.
- 天生的免疫分子,如补充受体 (CRs) 和托尔类受体 (TLRs) 在SScB细胞功能障碍中的作用尚不清楚.
- B细胞激活是SSc的一个早期事件,受CRs和TLRs的影响.
研究的目的:
- 为了研究B细胞在扩散皮肤SSc (dcSSc) 中的补充受体 (CR) 表达.
- 为了检查托尔类受体 (TLR) CD180结合对dcSSc B细胞中的CR表达的影响.
- 探索SSc相关的自身抗体,自然自身抗体和补充水平之间的相关性.
主要方法:
- 使用流细胞计分析了dcSSc患者和健康对照 (HC) 的B细胞上CD21,CD11c,CD11b和CD35的表达.
- 用CD180结合刺激B细胞,以评估CR表达的变化.
- 分析了抗Scl-70自身抗体,抗酸合成酶 (CS) 自然自身抗体和补充成分3 (C3) 水平之间的相关性.
主要成果:
- 在dcSSc和HC之间没有观察到基底CD21和CD11c表达的显著差异.
- 与HCs相比,dcSSc B细胞中发现了基底CD11b表达的减少.
- CD180结合导致dcSSc B细胞的CD35减少和CD11c表达增加,可能促进血细胞的形成和自身抗体的产生.
- 在dcSSc患者中发现了C3和anti-CS自身抗体水平之间的负相关性,这表明自然自身抗体激活了补充.
结论:
- 改变补体受体表达和对dcSSc中B细胞CD180结合的反应可能会导致自身抗体的产生.
- 自然的自身抗体可能会激活补体系统,导致SSc.中的组织损伤.
- 这些发现突出了先天免疫和B细胞功能障碍在SSc病变发生过程中的相互作用.
关键词:
B 细胞 B 细胞 B 细胞C3 C3 C3 C3 C3 C3 C3 C3 C3 C3 C3 C3 C3 C3 C3 C3 C3 C3 C3 C3 C3CD180 CD180 CD180 CD180 CD180 CD180 CD180 CD180 CD180 CD180 CD180 CD180 CD180 CD180 CD180 CD180 CD180 CD180 CD180 CD180 CD180 CD180 CD180 CD180 CD180 CD180 CD180 CD2 CD2 CD2 CD2 CD2 CD3 CD4 CD2 CD2 CD2 CD3 CD2 CD4 CD2 CD2 CD3 CD2 CD2 CD2 CD3 CD4 CD2 CD2 CD2 CD2 CD3 CD2 CD2 CD2 CD3 CD2 CD4 CD2 CD2 CD2 CD2 CD3 CD2 CD2 CD2 CD2 CD3 CD2 CD4 CD2 CD2 CD2 CD2 CD3 CD2 CD2 CD2 CD3 CD4 CD2 CD2 CD2 CD3 CD2 CD4 CD2 CD2 CD2 CD2 CD3 CD4 CD2 CD2 CD2 CD2 CD2 CD3 CD2 CD2 CD4 CD2 CD2 CD2 CD2 CD2 CD2 CD3 CD2 CD2 CD2 is what is what is what is what is what is收费类受体的收费类受体.对抗Scl-70的自身抗体.补充受体是一种补充受体.自然的自身抗体是自然的自身抗体.系统性硬化症 系统性硬化症相关概念视频
T Cell Types and Functions
961
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
961
T Cell Activation and Clonal Selection
688
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Naive T cells that have not yet encountered an antigen express two primary CD...
688
Diversity of Antigen Receptors
541
Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
541
B Cell Activation and Differentiation
1.6K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
1.6K


