使用尿液生物标志物来区分膀功能障碍在有感觉膀疾病的妇女
Yu-Chen Chen1,2,3, Yuan-Hong Jiang4, Jia-Fong Jhang4
1Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80756, Taiwan.
International journal of molecular sciences
|September 14, 2024
概括
这项研究确定了关键的尿液生物标志物,以区分感觉性膀疾病,如脱子过活 (DO) 和过敏膀 (HSB). 这些生物标志物,包括TNF-α和IP-10,为改善诊断和治疗提供了一种非侵入性方法.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 生物标志物发现发现
- 诊断医学 诊断医学 诊断医学
背景情况:
- 感觉膀疾病由于重叠的症状而带来诊断挑战.
- 准确的区分对于有效的患者管理和治疗策略至关重要.
研究的目的:
- 评估特定的尿液生物标志物,以区分非汉纳间歇性囊炎 (NHIC),脱子过活 (DO),过敏膀 (HSB) 和健康对照.
- 评估这些生物标志物的诊断性能在191名妇女的队列中.
主要方法:
- 对191名接受视频尿动力学研究 (VUDS) 的女性进行了回顾性分析.
- 测量尿液炎症和氧化应激生物标志物,包括IP-10,TAC,8-OHdG,IL-2和TNF-α.
- 分类为DO,HSB,NHIC和正常对照组.
主要成果:
- 在DO患者中增加IP-10;在HSB患者中降低TAC和8-OHdG.
- 在NHIC患者中降低IL-2和提高TNF-α,TNF-α对NHIC具有很高的敏感性和特异性.
- 针对IP-10,TAC和8-OHdG的具体值在区分DO和HSB方面已经证明有用.
结论:
- 尿液生物标志物如TNF-α,IP-10,TAC,8-OHdG和IL-2显示出对感觉膀疾病的非侵入性诊断有希望.
- 这些生物标志物可以帮助区分NHIC,DO和HSB,从而有可能改善临床管理.
相关概念视频
01:23Urinary Bladder
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The urinary bladder is a hollow, muscular sac that temporarily stores urine before it is expelled from the body. It can hold approximately 600 mL of urine prior to micturition. The bladder is retroperitoneal and located behind the pubic symphysis in the pelvic floor.
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
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01:26The Micturition Reflex
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Urination, or micturition involves the coordination of the bladder's detrusor muscle and two sphincters to ensure controlled bladder emptying.
The process begins with bladder filling, where the bladder wall stretches as urine accumulates. This stretching activates the urine storage reflex, mediated by the sacral spinal segments and the pontine storage center. Efferent sympathetic impulses stimulate the detrusor muscle to relax and the internal urethral sphincter to contract, facilitating...
The process begins with bladder filling, where the bladder wall stretches as urine accumulates. This stretching activates the urine storage reflex, mediated by the sacral spinal segments and the pontine storage center. Efferent sympathetic impulses stimulate the detrusor muscle to relax and the internal urethral sphincter to contract, facilitating...
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01:20Disorders of the Urinary System
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The urinary system is responsible for eliminating waste and excess fluids from the body. However, disorders of the urinary system can arise due to various reasons like infections, stress, age, congenital abnormalities, and lifestyle.
Urinary tract infections (UTIs) are one of the most common urinary system disorders. They are caused by bacteria that enter the urethra and can spread to the bladder resulting in cystitis. Pyelonephritis is the result of a UTI that has ascended to the level of the...
Urinary tract infections (UTIs) are one of the most common urinary system disorders. They are caused by bacteria that enter the urethra and can spread to the bladder resulting in cystitis. Pyelonephritis is the result of a UTI that has ascended to the level of the...
264