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中皮膜临床和心脏代谢疾病 - - 一枚硬币的两面?

Csaba Papp¹, Angela Mikaczo^2,3, Janos Szabo¹

¹Department of Psychiatry, Faculty of Medicine, University of Debrecen, Nagyerdei krt. 98, H-4032 Debrecen, Hungary.

International journal of molecular sciences

|September 14, 2024

概括

慢性非传染性疾病 (NCD) 和精神障碍与中皮层临系统 (MCL) 有着共同的联系. 这项研究确定了MCL疾病的新型治疗点,表明共享的病理和药物重定向的潜力.

科学领域:

神经科学是一个神经科学.
药理学药理学是指药理学的学科.
计算生物学计算生物学

背景情况:

慢性非传染性疾病 (NCD),如与滥用酒精,饮食不良,吸烟和久坐不动的生活方式相关的疾病,与中皮层临床系统 (MCL) 功能的改变有关.
该MCL电路是奖励途径的组成部分,并与风险行为和精神障碍有关,这表明统一治疗方法的潜力.

研究的目的:

测试NCD和涉及MCL系统的精神障碍具有共同的病理,并且可以集体治疗目标的假设.
通过使用集成计算策略来识别MCL疾病的新型分子标.

主要方法:

在MetaBaseTM和Integrity®数据库中采用基于知识,基于网络和疾病相似性算法.
利用机器学习来整合来自不同算法方法的分数来确定目标优先级.
已验证的机器学习模型性能与已知的目标,实现高精度 (AUC ~93%).

主要成果:

创建了250个潜在的治疗点的优先清单,用于MCL疾病.
已确认的已知标 (例如多巴胺,血清素受体) 和已确定的新兴标 (例如DPP4,PPARG,NOS1,ACE,CREB1,Ca2+通道).

结论:

这些发现支持了MCL电路障碍和NCD之间共享分子病理的假设.
确定了新的目标,为药物重新定位和推进个性化医疗提供了潜在的潜力,用于一系列相关疾病.

关键词:

机器学习是机器学习.中皮层临系统中皮层临系统网络分析网络分析非传染性疾病是非传染性疾病.目标优先级目标优先级.

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