含有原子的和它们的糖化的抗菌活性
Agnieszka Krawczyk-Łebek1, Barbara Żarowska2, Tomasz Janeczko1
1Department of Food Chemistry and Biocatalysis, Faculty of Biotechnology and Food Science, Wrocław University of Environmental and Life Sciences, 50-375 Wrocław, Poland.
International journal of molecular sciences
|September 14, 2024
概括
通过使用真菌进行糖化增强的化石,对各种细菌和酵母菌具有强大的抗微生物活性. 这些改性化合物在对抗微生物感染方面提供了有前途的应用.
科学领域:
- 自然产品化学 自然产品化学
- 生物技术是生物技术.
- 微生物学 微生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 哈尔科因是具有多种生物活动的植物代谢物.
- 和葡萄糖基替代剂可以增强石墨烯的生物活性和生物可用性.
- 结合化学和生物技术的方法是有效的生产改性石英.
研究的目的:
- 使用丝状真菌合成和糖化化酸盐.
- 为了研究石墨板结构上的糖化位点.
- 评估抗菌性质并预测产生的化合物的药理动力学.
主要方法:
- 4-chloro-2'-hydroxychalcone和5'-chloro-2'-hydroxychalcone的化学合成. 这两种化学合成的方法是:
- 使用真菌菌株 *Isaria fumosorosea* KCH J2 和 *Beauveria bassiana* KCH J1.5.5 的合成石墨烯的糖化.
- 化学信息学用于药理动力学预测和针对各种细菌和酵母菌株的抗菌活性测试.
主要成果:
- 糖化发生在C-2'和C-3位置,根据真菌菌株而异.
- 化石显示出对大肠杆菌,金黄色葡萄球菌和白菌的显著抑制.
- 在*Pseudomonas aeruginosa*中观察到高耐药性,而乳酸细菌显示出不同的敏感性.
结论:
- 与非化对应物相比,用替代的石英具有更强的抗菌疗效.
- 菌的糖基化是一种可行的方法来修改石墨板的特性.
- 这项研究突出了这些改造的石英作为抗菌剂的潜力.
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