生物医疗复合材料的聚烯/氧酸盐用于生物:全面解释的强化课程
Markos Petousis1, Nikolaos Michailidis2,3, Apostolos Korlos4
1Department of Mechanical Engineering, Hellenic Mediterranean University, 71410 Heraklion, Greece.
Polymers
|September 14, 2024
概括
将酸 (HAp) 添加到多[ε-caprolactone] (PCL) 中,显著提高了3D打印支架的强度. 在PCL/HAp复合物中,重量为6.0kg. %证明了骨组织工程的增强机械和结构性质.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物科学 聚合物科学
- 组织工程是组织工程.
背景情况:
- 聚[ε-caprolactone] (PCL) 是一种广泛用于医疗应用的生物相容聚合物,包括骨组织工程支架.
- 然而,PCL固有的机械弱点限制了其在承载应用中的使用.
- 用强大的,生物相容的添加剂增强PCL的机械性能对于先进的医疗用途至关重要.
研究的目的:
- 调查酸 (HAp) 添加对PCL机械和结构性质的影响,用于3D生物打印应用.
- 确定最佳的HAp度,以提高PCL在骨组织工程支架中的性能.
- 评估PCL/HAp复合材料的适用性,这些复合材料是通过生物工艺制造的.
主要方法:
- 聚[ε-caprolactone] (PCL) 与不同度的酸 (HAp) (0.0-8.0重量) 相结合. 百分之一). %).
- 复合材料被加工成纤维,然后使用生物切割3D打印制造成标本.
- 样品进行了全面的表征,包括热,,机械 (拉力,),形态 (SEM),化学 (EDS) 和结构 (微型CT) 分析.
主要成果:
- 添加HAp通常会提高PCL复合材料的机械强度.
- 微计算机断层扫描显示,增强结构完整性和减少空洞与HAp的合并.
- 这种PCL/HAp复合物具有6.0重量. % HAp在机械性能方面表现出最显著的改善,强度增加了14.6%.
结论:
- 酸 (HAp) 在3D打印应用中有效地作为聚[ε-caprolactone] (PCL) 的增强填充剂.
- 在PCL/HAp 6.0重量. %复合材料表现出优越的机械和结构特性,适合骨组织工程.
- 这项研究验证了HAp作为生物相容添加剂的使用,以增强PCL基材料用于先进的医疗支架.
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